Evidence map›Paper›PMID 42089928›Full record

ArticleDrug delivery and translational research2026

Transdermal ropivacaine delivery via hydrogel-forming microneedles: A pain-free alternative for local anaesthesia.

Andang Miatmoko, Qonita Kurnia Anjani, Rifda Tarimi Octavia, Natalia Porfiryeva, Febri Annuryanti, Gwan Young Kim, Ji Yeon Heo, Gwangheum Yoon, Ahreum Choi, Ryan F Donnelly

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Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andang MiatmokoDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C UNAIR Mulyorejo, Surabaya, 60115, Indonesia. andang-m@ff.unair.ac.id.
Qonita Kurnia AnjaniSchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. qonita.anjani@qub.ac.uk.
Rifda Tarimi OctaviaMaster Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C UNAIR Mulyorejo, Surabaya, 60115, Indonesia.
Natalia PorfiryevaSchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK.
Febri AnnuryantiDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C UNAIR Mulyorejo, Surabaya, 60115, Indonesia.
Gwan Young KimLife Science Research Institute, Daewoong Pharmaceutical Co., Ltd, Yongin-si, 17028, Republic of Korea.
Ji Yeon HeoLife Science Research Institute, Daewoong Pharmaceutical Co., Ltd, Yongin-si, 17028, Republic of Korea.
Gwangheum YoonLife Science Research Institute, Daewoong Pharmaceutical Co., Ltd, Yongin-si, 17028, Republic of Korea.
Ahreum ChoiLife Science Research Institute, Daewoong Pharmaceutical Co., Ltd, Yongin-si, 17028, Republic of Korea.
Ryan F DonnellySchool of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, UK. r.donnelly@qub.ac.uk.

Funding

Kementerian Riset, Teknologi dan Pendidikan Tinggi 040/E5/PG.02.00.PL/2024 and UN3.LPPM/PT.01.03/2024
6 · The paper itself

Abstract

Surgical procedures in critical care settings are often associated with prolonged postoperative pain, which remains a significant clinical challenge. Conventional analgesic strategies typically rely on injection-based delivery, which is invasive, requires trained personnel, and carries risks such as infection and tissue damage. To address these limitations, this study developed a minimally invasive transdermal delivery system for the local anaesthetic ropivacaine (ROP) using hydrogel-forming microneedles (HFMNs) combined with drug reservoir tablets. Two HFMN formulations were prepared using Gantrez

Indexed as

hydrogel-forming microneedleslocal anaesthesiapostoperative painRopivacainetransdermal

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.