ArticleBulletin of mathematical biology2026
From Trait-Structured Within-Host Dynamics to SIR Models: A Multiscale Framework With Re-Exposure.
Article in Bulletin of mathematical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We present a threshold-based multiscale framework that links mechanistic within-host infection dynamics to a structured, SIR-like population model. Starting from a two-variable system for pathogen load and immune response that includes inoculum (Allee-like) thresholds and nonlinear immune activation, we derive mapping rules that classify continuous trajectories into four states: susceptible (S), infected with low immune protection (
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