Observational studyLa Radiologia medica2026
Physio-metabolic MRI of oxygen metabolism and neovascularization for differentiating glioblastomas from solitary NSCLC brain metastases.
Observational study in La Radiologia medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeDistinguishing glioblastoma (GBM) from large solitary brain metastases (LBM > 1.5 cm) is crucial for tailoring therapy and optimizing outcomes. We used MRI-derived neovascularization and oxygen metabolism tumor microenvironment (TME) mapping to differentiate GBM from non-small cell lung cancer (NSCLC) origin-LBM. MATERIAL AND
methodsThis observational study included 21 GBM and 27 LBM patients who underwent physio-metabolic MRI. Imaging parameters related to oxygen metabolism (oxygen extraction fraction [OEF], cerebral metabolic rate of oxygen [CMRO
resultsCompared to LBM, GBM showed lower hypoxia without neovascularization and total hypoxia percentage (q = 0.007 and 0.0035, respectively), higher aerobic glycolysis and vital tumor percentage (q = 0.0023 and < 0.007, respectively). In subregions, GBM displayed higher PO
conclusionsPhysio-metabolic MRI provides noninvasive, quantitative insights into the heterogeneity of tumor microenvironment characteristics, show potential for preoperative discrimination between GBM and LBM. However, larger multicenter validation studies with diverse metastasis types are needed before widely clinical implementation.
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