Evidence map›Paper›PMID 42089901›Full record

ArticleProtoplasma2026

Bioinformatics analysis and differential tissue expression of the IGFBP4 gene in beef cattle.

Ruirui Song, Bingzhi Li, Sihu Wang, Maryam Alenize, Yanqing Zhao, Aaishah M H Kaabi, Afnan O Deebani, Wasimah AlShammari, Dalal Alenizi, Dalal Alardan and 1 more

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Article in Protoplasma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Ruirui SongCollege of Animal Science and Technology, Southwest University, No.160 College Road, 402460, Rongchang, Chongqing, China.
Bingzhi LiCollege of Animal Engineering, Yangling Vocational and Technical College, Yangling, 712100, Shaanxi, P.R. China.
Sihu WangCollege of Life Science, Yulin University, Yulin, 719000, China.
Maryam AlenizeDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia.
Yanqing ZhaoCollege of Animal Science and Technology, Southwest University, No.160 College Road, 402460, Rongchang, Chongqing, China.
Aaishah M H KaabiDepartment of Biology, College of Science, Qassim University, Qassim, Kingdom of Saudi Arabia.
Afnan O DeebaniDepartment of Biology, College of Science, University of Hafr Al Batin, P.O. Box 1803, 31991, Hafr Al Batin, Saudi Arabia.
Wasimah AlShammariDepartment of Biology, College of Science, University of Hail, Hail, 2440, Saudi Arabia.
Dalal AleniziDepartment of Biology, College of Science, University of Hail, Hail, 2440, Saudi Arabia.
Dalal AlardanDepartment of Biology, College of Science, University of Hail, Hail, 2440, Saudi Arabia.
Wenzhen ZhangCollege of Animal Science and Technology, Southwest University, No.160 College Road, 402460, Rongchang, Chongqing, China. zwz0909@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IGFBP4 is essential for adipogenesis and is highly expressed in adipocytes and osteoblasts of mice. However, its role in bovine adipogenesis, especially intramuscular adipogenesis, remains unknown. Here, we cloned the CDS of IGFBP4 from Qinchuan cattle and analyzed its protein structure and function. We measured its expression levels in various tissues. The CDS region of the bovine IGFBP4 gene was 777 bp long, encoding a protein of 259 amino acids. The in-silico analysis revealed sequence conservation of Bos mutus and Bos indicus, while variation was found in Mus musculus and Rattus norvegicus sequences. The physical and chemical properties of the IGFBP4 protein exhibited an isoelectric point of 7.10 and a molecular mass of 27.89 kDa. The protein was predicted to be hydrophilic and lacked a transmembrane structure, with potential phosphorylation and glycosylation sites. Interaction analysis suggested associations with several other proteins. Regarding tissue expression, the mRNA level of the IGFBP4 gene was highest in the liver, lowest in muscle, and significantly higher in subcutaneous fat compared to intramuscular fat in Qinchuan beef cattle. These findings indicate a potential role of theIGFBP4 gene in regulating bovine adipogenesis and lipid metabolism. This study provides a foundation for exploring the underlying molecular mechanism of intramuscular fat deposition in cattle.

Indexed as

Computational BiologyInsulin-Like Growth Factor Binding Protein 4Amino Acid SequenceAnimalsCattleGene Expression RegulationInsulin-Like Growth Factor Binding Protein 4Bioinformatics analysisIGFBP4 geneQinchuan cattleTissue expression profile

Identifiers

PMID42089901

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.