ArticleTurk gogus kalp damar cerrahisi dergisi2026
D-Valine as a mirror-image antifibrotic agent: Inhibiting fibroblast proliferation and attenuating airway fibrosis.
Article in Turk gogus kalp damar cerrahisi dergisi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Postintubation tracheal stenosis is a fibroproliferative airway disorder with limited pharmacological treatment options. Excessive fibroblast proliferation and extracellular matrix deposition play a central role in its pathogenesis. D-amino acids such as D-Valine are thought to modulate L-Valine-dependent protein synthesis, thereby suppressing fibroblast activity. This study aimed to evaluate the antifibrotic effects of D-Valine in experimental models. Methods: This study evaluated the antifibrotic effects of D-Valine using both Results: Conclusion: This study provides experimental evidence that D-Valine suppresses fibroblast proliferation and attenuates fibrosis in a New Zealand White rabbit model of tracheal stenosis. The antifibrotic effects observed may be related to interference with valine-dependent protein synthesis. However, considering the concurrent effects on epithelial cells and the inherent limitations of experimental models, further mechanistic and translational studies are required before potential clinical implications can be considered. These findings suggest that D-Valine represents a promising experimental antifibrotic candidate for airway fibrosis research.
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