Evidence map›Paper›PMID 42089860›Full record

ArticleJACC. Asia2026

Atrial Fibrillation and Clinical Outcomes Following Mitral Transcatheter Edge-to-Edge Repair According to Mitral Regurgitation Etiology.

Tetsu Tanaka, Masaki Izumo, Shingo Kuwata, Taishi Okuno, Daisuke Miyahara, Yoshihiro J Akashi, Masanori Yamamoto, Shunsuke Kubo, Mike Saji, Yuki Izumi and 18 more

Abstract read
In one paragraph

Article in JACC. Asia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Tetsu TanakaDepartment of Cardiology, St Marianna University School of Medicine, Kawasaki, Japan. Electronic address: https://twitter.com/TETSUTANAKA5.
Masaki IzumoDepartment of Cardiology, St Marianna University School of Medicine, Kawasaki, Japan. Electronic address: heartizumo@yahoo.co.jp.
Shingo KuwataDepartment of Cardiology, St Marianna University School of Medicine, Kawasaki, Japan.
Taishi OkunoDepartment of Cardiology, St Marianna University School of Medicine, Kawasaki, Japan.
Daisuke MiyaharaDepartment of Cardiology, St Marianna University School of Medicine, Kawasaki, Japan.
Yoshihiro J AkashiDepartment of Cardiology, St Marianna University School of Medicine, Kawasaki, Japan.
Masanori YamamotoDepartment of Cardiology, Toyohashi Heart Center, Toyohashi, Japan; Department of Cardiology, Gifu Heart Center, Gifu, Japan; Department of Cardiology, Nagoya Heart Center, Nagoya, Japan.
Shunsuke KuboDepartment of Cardiology, Kurashiki Central Hospital, Kurashiki, Japan.
Mike SajiDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan; Division of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
Yuki IzumiDepartment of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.
Yusuke EntaDepartment of Cardiology, Sendai Kosei Hospital, Sendai, Japan.
Shinichi ShiraiDivision of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.
Shingo MizunoDepartment of Cardiology, Shonan Kamakura General Hospital, Kanagawa, Japan.
Yusuke WatanabeDepartment of Cardiology, Teikyo University School of Medicine, Tokyo, Japan.
Makoto AmakiDepartment of Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan.
Kazuhisa KodamaDivision of Cardiology, Saiseikai Kumamoto Hospital Cardiovascular Center, Kumamoto, Japan.
Junichi YamaguchiDepartment of Cardiology Tokyo Woman's Medical University, Tokyo, Japan.
Toru NaganumaDepartment of Cardiology, New Tokyo Hospital, Chiba, Japan.
Hiroki BotaDepartment of Cardiology, Sapporo Higashi Tokushukai Hospital, Sapporo, Japan.
Yohei OhnoDepartment of Cardiology, Tokai University School of Medicine, Isehara, Japan.
Masahiko AsamiDivision of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan.
Daisuke HachinoheDepartment of Cardiology, Sapporo Heart Center, Sapporo Cardiovascular Clinic, Sapporo, Japan.
Masahiro YamawakiDepartment of Cardiology, Saiseikai Yokohama City Eastern Hospital, Kanagawa, Japan.
Hiroshi UenoSecond Department of Internal Medicine, Toyama University Hospital, Toyama, Japan.
Kazuki MizutaniDivision of Cardiology, Department of Medicine, Kindai University Faculty of Medicine, Osaka, Japan.
Toshiaki OtsukaDepartment of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan.
Kentaro HayashidaDepartment of Cardiology, Keio University School of Medicine, Tokyo, Japan.
OCEAN-Mitral Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between atrial fibrillation (AF) and prognosis after mitral transcatheter edge-to-edge repair (M-TEER) remains unclear.

objectivesThe authors examined the association between AF and clinical outcomes after M-TEER according to the etiology of mitral regurgitation (MR).

methodsA total of 3,764 patients were classified into degenerative mitral regurgitation (DMR), ventricular functional mitral regurgitation (VFMR), and atrial functional mitral regurgitation (AFMR). We further stratified the patients by the presence of AF. The primary outcome was all-cause mortality within 2 years.

resultsThe prevalence of AF was 57.4% (n = 646 of 1,126) in DMR, 59.7% (n = 1,319 of 2,211) in VFMR, and 83.8% (n = 358 of 427) in AFMR. During 2-year follow-up (the median follow-up: 427 [IQR: 301-821] days), 660 of 3,764 patients (17.5%) died. The association between AF and all-cause mortality had a significant interaction with MR etiology (P for interaction <0.001). AF was associated with a higher risk of all-cause mortality in DMR (adjusted HR: 1.88; 95% CI: 1.17-3.02; P = 0.009), whereas this association was not significant in VFMR and AFMR. Among patients with VFMR, left atrial (LA) volume index modified the association between AF and all-cause mortality. AF was related to a higher risk of all-cause mortality in VFMR patients with lower LA volume index, whereas this association was attenuated in those with higher LA volume index.

conclusionsAF was associated with all-cause mortality after M-TEER in patients with DMR, but not in those with VFMR or AFMR. The prognostic effect of AF in patients undergoing M-TEER may be modulated by MR etiology and underlying LA remodeling.

Indexed as

atrial fibrillationetiology of mitral regurgitationmitral regurgitationtranscatheter edge-to-edge repair

Identifiers

PMID42089860
PMCPMC13458923

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