ArticleAmerican journal of respiratory and critical care medicine2026
Role of casual contact in drug-resistant tuberculosis transmission: a molecular epidemiology study.
Article in American journal of respiratory and critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
rationaleTransmission is the primary driver of tuberculosis (TB) and drug-resistant TB (DR-TB) in high-burden countries; however, where and between whom spread occurs is poorly understood.
objectivesWe conducted universal whole genome sequencing (WGS) to evaluate the role of casual contact in Mycobacterium tuberculosis transmission.
methodsWe recruited persons diagnosed with second-line DR-TB (eg, extensively drug-resistant [XDR], pre-XDR-TB) from June 2018 to December 2022 in metropolitan Durban, South Africa. We collected named contacts and GPS coordinates of homes, clinics, and community locations visited regularly before diagnosis. Among participants genotypically clustered by whole genome sequencing (≤12 single-nucleotide polymorphisms), we quantified the proportion attributable to close versus casual contact. Close contact was defined as person-to-person links or overlapping hospitalizations. Casual contact links were based on geographic proximity of homes and community locations, or shared outpatient clinics. MEASUREMENTS AND MAIN
resultsWe enrolled 305 of 383 (80%) persons diagnosed with second-line DR-TB. TB isolates were sequenced for 251 (83%) participants; 141 (56%) were genotypically linked, forming 25 clusters (range, 2-49 persons/cluster). Among clustered participants, 69 (49%) were epidemiologically linked by casual contact and 13 (9%) through close contact. Multivariable analysis identified living within 1 km (OR, 17.9), visiting proximate community locations (OR, 1.88), shared outpatient clinic (OR, 1.72), and person-to-person links (OR, 5.38) as significant risk factors associated with genotypic clustering.
conclusionsCasual contact in community locations accounted for half of transmission among genotypic clusters in a high-burden setting. Efforts to curb TB will require a greater emphasis on community-based measures to identify cases from casual contact or undetected intermediate cases, in addition to the current mainstay of contact tracing.
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