A phage-derived reconfigurable effector associated with an actinobacterial contractile nanomachine tailors bacterial responses to competition.

Toshiki Nagakubo, Tatsuya Nishiyama, Shumpei Asamizu, Hiroyasu Onaka, Nobuhiko Nomura, Masanori Toyofuku

Abstract read

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Article in Journal of bacteriology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Toshiki NagakuboInstitute of Life and Environmental Sciencesm, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0003-0661-0304

Tatsuya NishiyamaLife Science Research Center, Nihon University, Fujisawa, Japan.

Shumpei AsamizuEngineering Biology Research Center, Kobe University, Kobe, Japan.ORCID 0000-0002-7178-5410

Hiroyasu OnakaGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Japan.

Nobuhiko NomuraInstitute of Life and Environmental Sciencesm, University of Tsukuba, Tsukuba, Japan.

Masanori ToyofukuInstitute of Life and Environmental Sciencesm, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0003-4627-9230

Funding

Japan Science and Technology Agency JPMJMI21G8, JPMJGX23B2Japan Society for the Promotion of Science 20J001208, 23K13863, 25K21728Japan Society for the Promotion of Science 23H05471Japan Society for the Promotion of Science 23K26811

6 · The paper itself

Abstract

Contractile injection systems (CISs) are derivatives of phage tails and are widely distributed in prokaryotes. CISs load cognate effectors and eject them through contractile actions resembling those of phage tails. Ejected effectors play central roles in CIS functionality by acting on target cells and mediating various biological processes. Here, we report a novel group of CIS effectors related to phage tape measure protein, the transmembrane component of the phage infection machinery. This group is broadly distributed within the class Actinobacteria, one of the bacterial classes in which CIS gene clusters are highly conserved, and is represented by Sle1, a cognate effector of the intracellularly localized

Indexed as

ActinobacteriaBacteriophagesStreptomyces lividansViral Tail ProteinsBacterial ProteinsEscherichia coliBacterial ProteinsViral Tail ProteinsActinobacteriacontractile injection systemeffector functionsmicrobial interactionphageStreptomycestape measure protein

Identifiers

PMID42089638

DOI10.1128/jb.00532-25

PMCPMC13277306

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.