Evidence map›Paper›PMID 42089408›Full record

ArticleeLife2026

Natural xanthones as α-Mangostin induce vasorelaxation involving key gating residues in the S6 domain of BK channels.

Soenke Cordeiro, Robert Patejdl, Thomas Baukrowitz, Marianne A Musinszki

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Soenke CordeiroInstitute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany.ORCID https://orcid.org/0000-0002-1049-8303
Robert PatejdlDepartment of Human Medicine, Health and Medical University Erfurt, Erfurt, Germany.ORCID https://orcid.org/0000-0003-4587-4054
Thomas BaukrowitzInstitute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany.ORCID https://orcid.org/0000-0003-4562-0505
Marianne A MusinszkiInstitute of Physiology, Christian-Albrechts-University Kiel, Kiel, Germany.ORCID https://orcid.org/0000-0002-5597-6735

Funding

Deutsche Forschungsgemeinschaft 506373940
6 · The paper itself

Abstract

Polyphenolic compounds are widely explored for health benefits, including hypertension, but their active ingredients, molecular targets, and mechanisms remain poorly defined. We identify the xanthone Mangostin from

Indexed as

Ion Channel GatingLarge-Conductance Calcium-Activated Potassium ChannelsVasodilationXanthonesAnimalsBinding SitesGarcinia mangostanaHumansLarge-Conductance Calcium-Activated Potassium ChannelsmangostinXanthonesbiochemistryBKchemical biologyKCa1.1mangostinmolecular biophysicsmouseSlo1structural biologyvasorelaxationVSMC

Identifiers

PMID42089408
PMCPMC13148824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.