ArticleBiotechnology and bioengineering2026
Detergent Virus Inactivation in Chromatography Systems.
Article in Biotechnology and bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Detergent treatment is a widely utilized virus-inactivation step in therapeutic protein manufacturing to safeguard products. Traditionally, this operation is performed in an incubation vessel in batch mode. In this investigation, a methodology was developed to enable virus inactivation via a post-load, detergent-containing wash within a bind-elute chromatography process. Application of the non-ionic detergent Laureth 9 during the post-load wash achieved more than 4 logs of retrovirus inactivation. Chromatography control experiments conducted without detergent resulted in negligible virus inactivation. Simultaneous measurements of virus infectivity and genome copies distinguished the contributions of detergent-driven net virus inactivation from those of separation-driven net virus removal. These results establish a robust and simplified alternative approach for virus inactivation in therapeutic protein manufacturing.
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