ArticleJournal of surgical oncology2026
Hospital Volume and Post-Hepatectomy Liver Failure After Major Hepatectomy.
Article in Journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
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Abstract
backgroundPost-hepatectomy liver failure (PHLF) following major hepatectomy (MH) increases the risk of morbidity and death. The relationship between institutional MH volume, PHLF, and outcomes is not well characterized.
methodsAdults undergoing MH from 2014 to 2021 in the ACS NSQIP hepatectomy-targeted database were included. Rates of PHLF were compared based on hospital-level annual MH volume. Multivariable logistic regression evaluated the association between volume, PHLF grade, and outcomes.
resultsAcross 11,167 patients, PHLF incidence was 3.7% in low-volume, 5.5% in low-medium volume, 6.9% in medium-high volume, 11.8% in high-volume centers (p < 0.001). The adjusted odds ratio (aOR) for morbidity in grade B/C PHLF compared to those without PHLF was elevated in both lower-volume centers (quartiles 1-3), (11.2 [7.04-17.70]) and in high-volume centers, (8.47 [6.06-11.85]).
conclusionHigher annual major hepatectomy volume is associated with increased PHLF, which may be a function of complex disease treated at these institutions. PHLF precedes other adverse events affecting both high and low volume institutions. PHLF is an important target for quality improvement.
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