Evidence map›Paper›PMID 42089299›Full record

ArticleBirth defects research2026

Potential Effects of Prepubertal Exposure to Perfluorooctane Sulfonic Acid on the First Wave of Folliculogenesis in Young CD-1 Mice.

Bounleut Phanavanh, Jalina Moore, Amy Inselman, Xiaoqing Li, Kyung Sung, Pei-Hsuan Hung, Li You, Noriko Nakamura

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Article in Birth defects research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Bounleut PhanavanhNational Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.
Jalina MooreNational Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.
Amy InselmanNational Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.
Xiaoqing LiCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Kyung SungCenter for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Pei-Hsuan HungCenter for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.
Li YouCenter for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, Maryland, USA.
Noriko NakamuraNational Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA.

Funding

U.S. Food and Drug Administration
6 · The paper itself

Abstract

backgroundPerfluorooctane sulfonic acid (PFOS) belongs to a group of synthetic chemicals referred to as per- and polyfluoroalkyl substances (PFAS) that are known to degrade slowly. Exposure to PFOS has been reported to cause birth defects and disrupt female sex hormone levels in mice. However, to date, the direct effects of PFOS exposure on folliculogenesis in young animals have not been evaluated. Therefore, this study was conducted to examine the potential effects of in utero and prepubertal exposure to PFOS on follicle development in juvenile, female mouse pups.

methodsICR dams and young, female mouse pups were dosed with 0.1 mg/kg PFOS or saline (vehicle) via gavage beginning on gestation day (GD) 6 (plug positive = GD 0) through GD 17 (n = 11-17 per group) [in utero exposure] or postnatal day (PND) 7 (PND 0 = day of birth) through PND 21 (n = 22-29 per group) [prepubertal exposure]. Ovaries and blood were then collected from a pup/litter on PND 28 for analysis.

resultsThere were no adverse effects of PFOS exposure observed in the measured endpoints upon in utero exposure; however, statistically significant differences following prepubertal exposure were noted for serum estradiol levels, the total number of primordial follicles, and the transcript levels of Foxo1 and Gdf9.

conclusionThe preliminary findings suggest that prepubertal exposure to PFOS may affect follicle development by disrupting estradiol production and altering Foxo1 and Gdf9 gene expression. Further studies will be important to examine the mechanisms underlying prepubertal exposure to PFOS on folliculogenesis.

Indexed as

Alkanesulfonic AcidsFluorocarbonsOvarian FollicleAnimalsEstradiolFemaleGrowth Differentiation Factor 9MiceMice, Inbred ICROvaryPregnancyPrenatal Exposure Delayed EffectsAlkanesulfonic AcidsEstradiolFluorocarbonsGdf9 protein, mouseGrowth Differentiation Factor 9perfluorooctane sulfonic acidestradiol levelsfolliculogenesisin utero exposuremiceovaryperfluorooctane sulfonic acidprepubertal exposure

Identifiers

PMID42089299
PMCPMC13147321

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