Evidence map›Paper›PMID 42089290›Full record

ArticleAmerican journal of respiratory cell and molecular biology2026

Anellovirus-mediated interferon dysregulation enhances virus-induced lung injury.

Mudassir M Banday, Shahid Banday, Mizanur Rahman, Amelia O Harrison, Namrata Singh, Ryan M Moore, Mohd Moin Khan, Shruti Shankar, Yasufumi Goda, Antonio Coppolino and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Mudassir M BandayBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Shahid BandayDepartment of Molecular, Cell and Cancer Biology, UMass Chan Medical School, Worcester, MA, United States.
Mizanur RahmanBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Amelia O HarrisonCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, United States.
Namrata SinghDepartment of Pathology, Dana Farber Cancer Center, Boston, MA, United States.
Ryan M MooreCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, United States.
Mohd Moin KhanBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Shruti ShankarPulmonary and Critical Care, University of South Florida/Tampa General Hospital, Tampa, FL, United States.
Yasufumi GodaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Antonio CoppolinoBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Nusrath MovvalBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Stacy StuttsPulmonary and Critical Care, University of South Florida/Tampa General Hospital, Tampa, FL, United States.
Ann WoolleyBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Larry DishawPulmonary and Critical Care, University of South Florida/Tampa General Hospital, Tampa, FL, United States.
Hilary GoldbergBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Yohannes MebratuBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Shawn W PolsonCenter for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, United States.
Kapil N PatelPulmonary and Critical Care, University of South Florida/Tampa General Hospital, Tampa, FL, United States.
Amit GaggarPulmonary and Critical Care, University of Alabama at Birmingham, Birmingham, AL, United States.
Don HayesCincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, United States.ORCID 0000-0002-6734-6052
Nandini KrishnamoorthyBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Benjamin E GewurzBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
George WashkoBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Yohannes TesfaigziBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Rakshinda RehmanBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Nirmal S SharmaBrigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0001-6340-4844

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Shawn W Polson · 2012 to 2026
$67.2M
Microbial Dysbiosis in Chronic Lung Allograft DysfunctionR01HL161620 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Nirmal S Sharma · 2022 to 2026
$2.6M
The role of Bik in the replication and severity of influenza A virusR01AI148180 · NIAID · OHIO STATE UNIVERSITY · PI MEBRATU, YOHANNES AFEWORK · 2021 to 2025
$2.1M
Data Management and Storage System for Shared Resource FacilitiesS10OD028725 · OD · UNIVERSITY OF DELAWARE · PI POLSON, SHAWN W · 2021 to 2021
$600k
Delaware Biotechnology InstituteDelaware IDeA Network of Biomedical Research ExcellenceNHLBI NIH HHS R01 HL161620NIAID NIH HHS R01 AI148180NIGMS NIH HHS P20 GM103446NIH HHS 5R01HL161620NIH HHS S10 OD028725
6 · The paper itself

Abstract

objectivesTo characterize the lung virome after lung transplantation and test whether anelloviruses modulate innate immune responses that influence susceptibility to respiratory viral-associated allograft injury. RATIONALE: The lung virome (LV) and its interactions with the host immune system leading to allograft injury after lung -transplantation are not well characterized.

methodsShotgun metagenomics and qPCR was performed on a multicenter BAL/serum cohort from lung transplant recipients (LTRs). Viral constructs from a Betatorquevirus clade (BTV) and group 2 torque teno viruses were transfected in primary bronchial epithelial cells (PBECs) or airways of C57BL/6 mice with and without exposure to influenza A virus (IAV) or respiratory syncytial virus (RSV). MEASUREMENTS AND MAIN

resultsLV in LTRs was dominated by viruses from the family Anelloviridae. Chronic lung allograft dysfunction (CLAD) LV was characterized by the enrichment of BTV. Validation in an independent cohort confirmed BTV abundance in CLAD BAL fluid, serum, and lung tissues. BTV ORF1 protein (kV1) suppressed PBEC IFN-α and IFN-γ responses by preventing intranuclear STAT translocation. Co-culture of IAV or RSV in kV1-transfected PBECs significantly augmented replication of RSV and IAV and increased cellular injury. Likewise, in vivo transfection of kV1 increased replication and lung injury associated with IAV.

conclusionsOur work illuminates a novel virus-associated dysregulation of host interferon responses that promote lung injury associated with respiratory viral infections and, in part, explain differential host responses to viral infections after lung transplantation.

Indexed as

AnelloviridaeInterferonsLung InjuryAnimalsFemaleHumansInfluenza A virusLungLung TransplantationMaleMiceMice, Inbred C57BLRespiratory Syncytial VirusesInterferonsCLADInterferon responseslung allograft injuryTorqueTeno Virus

Identifiers

PMID42089290
PMCPMC13519345

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.