Evidence map›Paper›PMID 42089266›Full record

ArticleG3 (Bethesda, Md.)2026

Automated analysis of C. elegans behavior by LabGym: an open-source, AI-powered platform.

L Amanda Xu, Hongjiang Liu, Zhaoyu Li, X Z Shawn Xu, Bing Ye, Yujia Hu, Elizabeth A Ronan

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

L Amanda XuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, United States.ORCID 0009-0006-4557-6822
Hongjiang LiuQueensland Brain Institute, University of Queensland, St Lucia, QLD 4067, Australia.
Zhaoyu LiQueensland Brain Institute, University of Queensland, St Lucia, QLD 4067, Australia.
X Z Shawn XuLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, United States.
Bing YeLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109, United States.ORCID 0000-0002-8828-4065
Yujia HuCleveland Clinic Research, Cleveland, OH 44195, United States.
Elizabeth A RonanDepartment of Biologic and Materials Science, School of Dentistry, University of Michigan, Ann Arbor, MI 48109, United States.ORCID 0000-0001-7400-5718

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Neural and genetic mechanisms underlying mechanosensation in C. elegansR01DC018167 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YE, BING · 2020 to 2025
$2.3M
The assembly of population coding networksR01NS128500 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TZUMIN LEE · 2023 to 2026
$1.5M
LSI Innovation Partnership Fund T32 DC00011NIDCD NIH HHS R01 DC018167NIDCR NIH HHS T32 DE007057NIH HHS R01 DC018167NIH HHS R01 NS128500NINDS NIH HHS R01 NS128500
6 · The paper itself

Abstract

The genetic tractability, well-mapped circuitry, and diverse behavioral repertoire of the nematode C. elegans make it an ideal model for physiological and behavioral studies. A wide range of methods has been developed for analyzing C. elegans behaviors, evolving with advances in technology such as videography and computer-assisted analysis. Here, we introduce LabGym-an open-source, artificial intelligence (AI)-based platform we recently developed-to the C. elegans research community. We trained deep learning models in LabGym capable of automatically categorizing and quantifying multiple user-defined parameters of worm locomotion behavior in multi-worm videos with high accuracy. Furthermore, we demonstrated their efficacy in quantifying locomotion changes in aging worms. Our work offers a cost-effective, user-accessible approach to behavioral analysis in C. elegans.

Indexed as

Artificial IntelligenceBehavior, AnimalCaenorhabditis elegansSoftwareAnimalsAutomationImage Processing, Computer-AssistedIntelligent SystemsLocomotionartificial intelligencebehaviorC. eleganslocomotion

Identifiers

PMID42089266
PMCPMC13334171

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.