ReviewEssays in biochemistry2026
Synthetic microbial communities for studying the fate and ecological role of specialized metabolites.
Review in Essays in biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Synthetic microbial communities: emerging live biotherapeutics for targeted gut microbiome modulation.Gut microbes · 2026Review
- Bacterial biosynthetic gene clusters.Essays in biochemistry · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
A wide range of microbially produced specialized metabolites (SMs) with bioactivity affecting micro- and macro-organisms has been described. These bioactive compounds are synthesized by enzyme complexes encoded in biosynthetic gene clusters (BGCs). Historically, the first role of SMs was revealed through antimicrobial activity-based assays. However, diverse bioactivities have since been deciphered that are not associated with inhibition of other organisms. To advance discoveries in chemical ecology, synthetic microbial communities (SynComs), simplified, experimentally tractable systems that recapitulate specific features of natural microbiomes, are increasingly employed. SynComs enable the systematic investigation of SM-mediated induction of BGC expression, the characterization of SM bioconversions, and the elucidation of the mechanism by which SMs influence microbial establishment and persistence within communities. Due to their reduced complexity, SynComs allow the controlled determination of microbial community composition and functional dynamics, as well as the characterization of associated chemical diversity. This review highlights representative publications describing how SynComs are employed to elucidate the roles of SMs in complex microbial interactions and emphasizes the emerging functions observed in SynCom-based chemical ecology studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.