ArticleJournal of the American Heart Association2026
Associations of Brain Morphology and Cognitive Function With Ambulatory Estimated Pulse Wave Velocity.
Yi-Bang Cheng, Qian-Hui Guo, Yi Chen, Jin Zhang, Yuan-Yuan Kang, Ting-Yan Xu, Yan Li, Ji-Guang Wang
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In one paragraphArticle in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Yi-Bang Cheng *Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0000-0002-3822-3504 Qian-Hui Guo *Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Yi ChenDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0000-0002-7500-7114 Jin ZhangDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Yuan-Yuan KangDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0000-0001-9121-5872 Ting-Yan XuDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0009-0006-5637-4708 Yan LiDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.ORCID 0000-0002-5825-5968 Ji-Guang WangDepartment of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
backgroundInconsistent links between arterial stiffness and cognition may reflect limited cognitive tests and unaccounted diurnal pulse wave velocity variation. To bridge this knowledge gap, we investigated 24-hour ambulatory estimated pulse wave velocity (ePWV) and its association with dementia-related neuroimaging and cognitive function in hypertension.
methodsWe assessed 893 patients with hypertension aged ≥50 years (mean age, 67.2 years; 52.3% women), including brain magnetic resonance imaging (n=545), global cognitive testing (n=623), and ambulatory ePWV measurements. White matter hyperintensity and hippocampus were quantified via Computational Anatomy Toolbox 12 and Statistical Parametric Maps 12. Cognition was assessed via the Mini-Mental State Examination and Montreal Cognitive Assessment.
resultsAmong 623 tested participants, the prevalence of mild cognitive impairment was 10% (Mini-Mental State Examination, n=62) and 18.5% (Montreal Cognitive Assessment, n=115). Cognitive scores decline with higher white matter hyperintensity burden and lower hippocampal volume (
conclusionsAmbulatory ePWV is an independent risk factor for dementia-related brain pathology. Targeting arterial stiffness represents a promising strategy for dementia prevention.
Indexed as
BrainCognitionCognitive DysfunctionHippocampusHypertensionPulse Wave AnalysisVascular StiffnessWhite MatterAgedFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedambulatory estimated pulse wave velocitycognitionhippocampuswhite matter hyperintensity
Identifiers
PMID42089188
PMCPMC13279442
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