ArticleAdvanced healthcare materials2026
Chamber-Specific Decellularized Extracellular Matrices Differentially Modulate Cardiomyocyte Subtypes to Drive Engineered Heart Tissue Development and Function.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Decellularized extracellular matrix (dECM) preserves native biochemical and biophysical cues and serves as a functional biomaterial for engineered tissue development. While tissue-specific extracellular matrix (ECM) has been widely studied, regional variation within the same organ remains poorly understood. Here, we investigate chamber-specific roles of ventricular (vtdECM) and atrial (atdECM) dECMs in engineered heart tissue (EHT) formation using induced pluripotent stem cell-derived cardiomyocyte (CM) subtypes. Proteomic analysis revealed distinct compositional profiles, with vtdECM enriched in ventricular development-related proteins and atdECM enriched in structural organization-related proteins. Ventricular CMs exhibited enhanced maturation and function in vtdECM, whereas atrial CMs showed limited responsiveness to ECM composition despite transcriptome-level differences. Encapsulation timing further modulated these effects, with early encapsulation promoting structural maturation and late encapsulation enhancing calcium handling. These findings demonstrate that chamber-specific ECM composition and developmental timing cooperatively regulate subtype-specific CM maturation, providing a framework for designing physiologically relevant EHTs.
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