SynthesisPulmonary medicine2026
Association of Macrophage Migration Inhibitory Factor-794 CATT Microsatellite Polymorphism With Tuberculosis Risk: A Systematic Review and Meta-Analysis.
Synthesis in Pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculosis (TB) remains a major infectious cause of morbidity and mortality worldwide and is influenced by both environmental exposures and host genetic factors. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, plays an important role in immune and inflammatory responses. The MIF-794 CATT microsatellite polymorphism (rs5844572) in the promoter region may affect gene transcription and thereby influence susceptibility to TB. This systematic review and meta-analysis are aimed at evaluating the association between the MIF-794 CATT polymorphism and TB risk across different populations.
methodsA comprehensive literature search was performed in PubMed, Embase, Web of Science, Cochrane Library, and Google Scholar up to the latest available date. Case-control studies evaluating the association between the MIF-794 CATT polymorphism and TB susceptibility were included in accordance with PRISMA guidelines. Data from seven high-quality studies (Newcastle-Ottawa Scale score ≥ 8), comprising 1063 TB cases and 957 controls, were pooled. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated under allelic, dominant, and recessive genetic models using fixed- or random-effects models according to heterogeneity.
resultsThe pooled analysis suggested a possible association between longer CATT repeat alleles (CATT
conclusionsThe available evidence suggests that the MIF-794 CATT polymorphism may contribute to TB susceptibility, but the association remains modest, heterogeneous, and inconclusive overall. This variant should be regarded as a possible component of a broader immunogenetic framework rather than an established standalone biomarker. Further large-scale, multicentric, and functionally integrated studies are needed to clarify its role in TB risk.
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