ReviewFrontiers in fungal biology2025
Fungal small RNA: unveiling the breakthroughs and promising applications.
Review in Frontiers in fungal biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small RNAs (sRNAs) are abundant endogenous non-coding RNAs in eukaryotic organisms that regulate gene expression by binding to their target mRNAs either completely or partially. The rapid advancements in fungal sRNA research in recent years have significantly expanded our understanding of their biogenesis, functional mechanisms, and roles in fungal biology. Unlike previous reviews that predominantly focus on the intracellular biogenesis and regulatory networks of fungal sRNAs within fungal cells, this review uniquely bridges fungal sRNA molecular biology with plant pathology by centering on the bidirectional cross-kingdom RNAi trafficking between fungi and plants. We provide a comprehensive overview of fungal sRNA types, especially novel subtypes identified in recent studies, the key protein factors involved in their biogenesis, and the molecular mechanisms governing their intracellular functions. Additionally, we conduct an in-depth analysis of the trafficking routes of fungal sRNAs into host plants, their targeted interference with plant immune signaling cascades, and the reciprocal regulation of fungal physiology by plant-derived sRNAs. Finally, we discussed the potential applications of fungal sRNAs in biotechnology and pathogen control, particularly in the development of host-induced gene silencing (HIGS)/spray-induced gene silencing (SIGS)-based crop protection strategies. This work not only serves as a valuable reference for future studies on fungal sRNAs but also highlights the translational potential of cross-kingdom RNAi in plant-fungal pathosystems, filling critical gaps in existing literature.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.