Evidence map›Paper›PMID 42089082›Full record

ArticleMaterials futures2026

A clinically defined and xeno-free hydrogel system for regenerative medicine.

John Ong, George Gibbons, Yee Siang Lim, Lei Zhou, Junzhe Zhao, Alexander W Justin, Federico Cammarata, Ravisankar Rajarethinam, Colleen Limegrover, Sanjay Sinha and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials futures, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

John OngDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, United Kingdom.ORCID https://orcid.org/0000-0001-5103-7311
George GibbonsJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge CB2 0PY, United Kingdom.
Yee Siang LimGenome Institute of Singapore, 60 Biopolis St, Singapore 138672, Singapore.
Lei ZhouDepartment of Medicine, National University of Singapore, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
Junzhe ZhaoDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, United Kingdom.
Alexander W JustinDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, United Kingdom.
Federico CammarataDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, United Kingdom.ORCID https://orcid.org/0000-0003-2373-1167
Ravisankar RajarethinamInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.
Colleen LimegroverJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge CB2 0PY, United Kingdom.
Sanjay SinhaCambridge Stem Cell Institute, University of Cambridge, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge CB2 0AW, United Kingdom.
Andras LakatosJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge CB2 0PY, United Kingdom.
Foad J RouhaniDepartment of Surgery, Addenbrooke's Hospital, Hills Rd, Cambridge CB2 0QQ, United Kingdom.
Yock Young DanDepartment of Medicine, National University of Singapore, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
Athina E MarkakiDepartment of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, United Kingdom.ORCID https://orcid.org/0000-0002-2265-1256

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biofabricated scaffolds facilitate bona fide cellular interactions, cell type specification, and the formation of three-dimensional tissue architecture from human pluripotent stem cells (hPSCs). However, xenogenic biomaterials are poorly defined, and synthetic biomaterials remain underdeveloped and understudied, hindering regulatory approval for clinical use and preventing the translation of lab-grown therapies. Here, we describe a protein screen-based hydrogel system biofabricated from physiologically relevant human components. We show that 'Alphagel', a base hydrogel comprising human embryonic matrices, supports the trilineage differentiation of hPSCs into neural, cardiac, and liver tissue. Alphagel is also shown to be biocompatible and biodegradable

Indexed as

hydrogelliverregenerative medicinestem cellstissue engineering

Identifiers

PMID42089082
PMCPMC13138298

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.