ArticleDrug design, development and therapy2026
The Impact of Sex on the Median Effective Dose of Dexmedetomidine for Preoperative Sedation in Adults Undergoing Upper Limb Surgery: An Up-and-Down Sequential Allocation Study.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- ED50 and ED95 of Remimazolam Combined with Sufentanil for Sedation During Ultrasound-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids: A Prospective Dose-Finding Study.Drug design, development and therapy · 2026Article
- Adequate Sedation or Deep Sedation? Interpreting Sex-Neutral Dexmedetomidine ED50 Findings in Upper Limb Surgery [Letter].Drug design, development and therapy · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Prospective evidence on sex-based variability in the sedative potency of dexmedetomidine remains limited. This study aimed to estimate and compare the median effective dose (ED Patients and Methods: In this prospective, single-center, assessor-blinded, dose-finding study, adult patients aged 18 to 60 years scheduled for upper limb surgery were allocated to male and female dexmedetomidine groups according to biological sex. Dexmedetomidine was administered intravenously over 15 minutes using a modified Dixon's up-and-down sequential method (initial dose 1.0 μg/kg; step size 0.05 μg/kg). Adequate sedation was defined as a Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale score < 3 at 26 minutes from infusion start. The primary endpoint was the Dixon-derived ED Results: Forty-six patients (23 per group) were enrolled. The Dixon-derived ED Conclusion: No clinically meaningful sex-related difference was observed in dexmedetomidine ED
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