The association between the infarct-related artery and in-hospital and long-term mortality and major adverse cardiovascular events in patients with ST-segment elevation myocardial infarction.

Introduction: Despite advances in percutaneous coronary intervention (PCI), ST-segment elevation myocardial infarction (STEMI) remains associated with substantial morbidity and mortality, and the prognostic relevance of the infarct-related artery (IRA) remains controversial. Aim: This study evaluated the association between IRA location and in-hospital and long-term mortality and major adverse cardiovascular events (MACE) in STEMI patients undergoing primary PCI. Material and methods: This retrospective study included 693 consecutive STEMI patients treated with primary PCI between January 2015 and January 2016, with a mean follow-up of 103 months. Patients were classified according to IRA location as left anterior descending artery (LAD), left circumflex artery (LCx), or right coronary artery (RCA). In-hospital and long-term mortality and MACE were assessed. Results: Baseline characteristics were similar among groups. Left ventricular ejection fraction (LVEF) was significantly lower in the LAD group ( Conclusions: In STEMI patients undergoing primary PCI, IRA location was not an independent determinant of short- or long-term outcomes. Prognosis was mainly driven by myocardial function and systemic clinical factors.