ArticleFrontiers in neurology
CRP and D-dimer for risk stratification of cerebral infarction in children with
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Cerebral infarction (CI) is a rare but severe complication of Objective: This study aimed to explore the clinical characteristics and factors associated with CI in pediatric patients with MPP. Methods: A retrospective cohort study of children with MPP was conducted between 2019 and 2023. Clinical characteristics, laboratory findings, and imaging results were collected and analyzed. Propensity score matching (PSM) was applied to reduce potential confounding, and Firth's penalized logistic regression was performed as an exploratory analysis to assess associations between selected variables and CI. Results: Among 2,947 children diagnosed with MPP, 9 (0.3%) developed CI. In the matched cohort, higher levels of C-reactive protein (CRP) and D-dimer were significantly associated with the occurrence of CI [CRP: odds ratio (OR) = 1.08, Conclusion: Elevated CRP and D-dimer levels were associated with CI in children with MPP and may be useful for risk stratification. These findings highlight the potential interplay between inflammation and coagulation in CI complicating MPP. Further multicenter studies with larger sample sizes are required to validate these results and clarify their clinical utility.
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