SynthesisFrontiers in neurology
Endovascular therapy versus standard medical treatment for vertebrobasilar artery occlusion: a systematic review and meta-analysis.
Synthesis in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute vertebrobasilar artery occlusion (VBAO) is a devastating condition with high mortality and severe disability. Recent randomized controlled trials (RCTs) have significantly demonstrated that endovascular therapy is highly effective for VBAO, but its effectiveness for broader and real-world patient populations remains uncertain. This review aims to systematically evaluate the efficacy and safety of endovascular therapy for VBAO, integrating evidence from both RCTs and real-world data. Methods: We systematically searched PubMed, Embase, and the Cochrane Library from January 2000 to July 2025 for RCTs and observational cohort studies comparing endovascular therapy with standard medical treatment in patients with VBAO. Our primary outcome was 90-day favourable functional status, defined as a modified Rankin Scale score of 0 to 3. Secondary outcomes included functional independence (90-day modified Rankin Scale score of 0-2). Safety outcomes were symptomatic intracranial haemorrhage and 90-day mortality. Results: A total of 15 studies were included in the analysis, consisting of 4 RCTs ( Conclusion: This integrated analysis confirms endovascular therapy as a cornerstone treatment for acute vertebrobasilar artery occlusion, demonstrating significant improvements in functional outcomes and mortality despite increased symptomatic intracranial hemorrhage risk. Systematic review registration: https://inplasy.com/projects/, identifier INPLASY202590088.
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