Evidence map›Paper›PMID 42088849›Full record

ReviewFrontiers in aging2026

Risk genes in progressive supranuclear palsy (PSP) affect integrity and function of microtubules.

Timothy A Donlon, Ulrich Müller

Abstract readReview
In one paragraph

Review in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Timothy A DonlonDepartment of Research, Kuakini Medical Center, Honolulu, HI, United States.
Ulrich MüllerInstitute of Human Genetics, Justus-Liebig-University, Giessen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive supranuclear palsy (PSP) is a tauopathy and has a multifactorial etiology. The genetic component comprises at least 15 genes with unrelated functions that increase risk for PSP with a high degree of certainty. The function of these genes in increasing risk for PSP is presently unknown. This study was undertaken to identify new pathological pathways of these genes/proteins in increasing risk for PSP. Identification of possible targets and pathways of these genes was investigated using publicly available databases. 13 out of 15 of the risk genes, i.e.

Indexed as

autophagosomedementiamicrotubuleprogressive supranuclear palsyunfolded protein

Identifiers

PMID42088849
PMCPMC13136283

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.