Evidence map›Paper›PMID 42088846›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Criterion and convergent validity of plasma biomarkers in early-onset Alzheimer's disease: Initial findings from LEADS.

Dustin B Hammers, Angelina Polsinelli, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Tatiana Foroud, Sujuan Gao, Laurel Beckett, Renaud La Joie, Alexandra Touroutoglou and 36 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Dustin B HammersDepartment of Neurology Indiana University School of Medicine Indianapolis Indiana USA.
Angelina PolsinelliDepartment of Psychology Simon Frasier University Vancouver British Columbia Canada.
Ani EloyanDepartment of Biostatistics, Center for Statistical Sciences Brown University Providence Rhode Island USA.
Alexander TauroneDepartment of Biostatistics, Center for Statistical Sciences Brown University Providence Rhode Island USA.
Maryanne ThangarajahDepartment of Biostatistics, Center for Statistical Sciences Brown University Providence Rhode Island USA.
Tatiana ForoudDepartment of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA.
Sujuan GaoDepartment of Biostatistics Indiana University School of Medicine Indianapolis Indiana USA.
Laurel BeckettDepartment of Public Health Sciences University of California - Davis Davis California USA.
Renaud La JoieDepartment of Neurology University of California - San Francisco San Francisco California USA.
Alexandra TouroutoglouDepartment of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Prashanthi VemuriDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology The Sahlgrenska Academy, University of Gothenburg Mölndal Sweden.
Kaj BlennowEli Lilly and Company Indianapolis Indiana USA.
Sára NemesDepartment of Neurology Indiana University School of Medicine Indianapolis Indiana USA.
Ralitsa KostadinovaDepartment of Neurology Indiana University School of Medicine Indianapolis Indiana USA.
Paul AisenAlzheimer's Therapeutic Research Institute University of Southern California San Diego California USA.
Kelly N NudelmanDepartment of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA.
Kala KirbyDepartment of Neurology Indiana University School of Medicine Indianapolis Indiana USA.
Alireza AtriBanner Sun Health Research Institute Sun City Arizona USA.
David ClarkDepartment of Neurology Indiana University School of Medicine Indianapolis Indiana USA.
Gregory S DayDepartment of Neurology Mayo Clinic Jacksonville Florida USA.
Ranjan DuaraWien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center Miami Florida USA.
Neill R Graff-RadfordDepartment of Neurology Mayo Clinic Jacksonville Florida USA.
Ian GrantDepartment of Psychiatry and Behavioral Sciences Mesulam Center for Cognitive Neurology and Alzheimer's Disease Feinberg School of Medicine Northwestern University Chicago Illinois USA.
Lawrence S HonigTaub Institute and Department of Neurology Columbia University Irving Medical Center New York New York USA.
Erik C B JohnsonDepartment of Neurology and Human Genetics Emory University School of Medicine Atlanta Georgia USA.
David T JonesDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Joseph C MasdeuNantz National Alzheimer Center Houston Methodist and Weill Cornell Medicine Houston Texas USA.
Mario F MendezDepartment of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA.
Leila ParandDepartment of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA.
Kyle WomackDepartment of Neurology Washington University in St. Louis St. Louis Missouri USA.
Erik MusiekDepartment of Neurology Washington University in St. Louis St. Louis Missouri USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA.
Meghan RiddleDepartment of Neurology Alpert Medical School, Brown University Providence Rhode Island USA.
Emily RogalskiHealthy Aging & Alzheimer's Research Care Center, Department of Neurology University of Chicago Chicago Illinois USA.
Stephen SallowayDepartment of Neurology Alpert Medical School, Brown University Providence Rhode Island USA.
Sharon J ShaDepartment of Neurology & Neurological Sciences Stanford University Palo Alto California USA.
Raymond Scott TurnerDepartment of Neurology Georgetown University Washington D.C. USA.
Thomas S WingoDepartment of Neurology UC Davis Alzheimer's Disease Research Center University of California - Davis Davis California USA.
David A WolkDepartment of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA.
Maria C CarrilloMedical & Scientific Relations Division Alzheimer's Association Chicago Illinois USA.
Gil D RabinoviciDepartment of Neurology University of California - San Francisco San Francisco California USA.
Bradford C DickersonDepartment of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Jeffrey L DageDepartment of Neurology Indiana University School of Medicine Indianapolis Indiana USA.
Liana G ApostolovaDepartment of Neurology Indiana University School of Medicine Indianapolis Indiana USA.
LEADS Consortium

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI BANDEEN-ROCHE, KAREN J. · 1985 to 2019
$37.6M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI VAN DEERLIN, VIVIANNA M · 1991 to 2020
$35.1M
Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI VASSAR, ROBERT J · 1996 to 2020
$28.9M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
NIA NIH HHS K23 AG080071NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG072976NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG023501NIA NIH HHS P50 AG025688NIA NIH HHS P50 AG047366NIA NIH HHS R56 AG057195NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG057195NIA NIH HHS U24 AG021886
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cognitionearly‐onset Alzheimer's diseasemagnetic resonance imagingMRIPETplasma biomarkerspositron emission tomography

Identifiers

PMID42088846
PMCPMC13135914

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.