Evidence map›Paper›PMID 42088832›Full record

ArticleBioactive materials2026

Submolecular modulation of PIEZO1 mechanotransduction with wireless tailor-made nanoswitches.

Simão P B Teixeira, Alberto Pardo, Pablo Taboada, Brent M Bijonowski, Mariana T Carvalho, Jana B Nieder, Maja Wolleb, Jess G Snedeker, Manuela E Gomes, Rui M A Domingues

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PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Simão P B TeixeiraInternational Iberian Nanotechnology Laboratory (INL), Avenida Mestre José Veiga s/n, 4715-330, Braga, Portugal.
Alberto Pardo3B's Research Group, Research Institute on Biomaterials, Biodegradables and Biomimetics (I3Bs) of the University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque de Ciência e Tecnologia, Rua Ave 1, Edifício 1 (Sede), 4805-694, Barco GMR, Portugal.
Pablo TaboadaColloids and Polymers Physics Group, Particle Physics Department, Materials Institute (iMATUS), Health Research Institute (IDIS), University of Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Brent M BijonowskiInternational Iberian Nanotechnology Laboratory (INL), Avenida Mestre José Veiga s/n, 4715-330, Braga, Portugal.
Mariana T CarvalhoInternational Iberian Nanotechnology Laboratory (INL), Avenida Mestre José Veiga s/n, 4715-330, Braga, Portugal.
Jana B NiederInternational Iberian Nanotechnology Laboratory (INL), Avenida Mestre José Veiga s/n, 4715-330, Braga, Portugal.
Maja WollebDepartment of Orthopaedics, University Hospital Balgrist, University of Zurich, Lengghalde 5, CH-8008, Zurich, Switzerland.
Jess G SnedekerDepartment of Orthopaedics, University Hospital Balgrist, University of Zurich, Lengghalde 5, CH-8008, Zurich, Switzerland.
Manuela E Gomes3B's Research Group, Research Institute on Biomaterials, Biodegradables and Biomimetics (I3Bs) of the University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark - Parque de Ciência e Tecnologia, Rua Ave 1, Edifício 1 (Sede), 4805-694, Barco GMR, Portugal.
Rui M A DominguesInternational Iberian Nanotechnology Laboratory (INL), Avenida Mestre José Veiga s/n, 4715-330, Braga, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PIEZO mechanoreceptors play critical roles in fundamental physiological processes such as proprioception or musculoskeletal biomechanics. However, their complex gating mechanisms and downstream signaling are still not completely understood, mainly due to the lack of effective probing tools. Here, we combine molecular imprinting and magnetic concepts to develop tailor-made nanoswitches enabling wireless targeted actuation of PIEZO1. Two epitopes selected

Indexed as

Magnetic therapiesMechanobiologyMolecular imprintingPIEZO channelsStem cells

Identifiers

PMID42088832
PMCPMC13137217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.