Evidence map›Paper›PMID 42088831›Full record

ArticleToxicology reports2026

Presence of glyphosate in endometrial cancer tissue: A cross-sectional study.

Márkó Unicsovics, Apolka Szentirmay, Györgyi Fekécs, Patrik Plank, Zsófia Molnár, György Nagyéri, Katalin Posta, Nándor Ács, Szabolcs Várbíró, Levente Sára and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Márkó UnicsovicsDepartment of Obstetrics and Gynecology, Semmelweis University, Baross utca 27, Budapest 1088, Hungary.
Apolka SzentirmayDepartment of Obstetrics and Gynecology, Semmelweis University, Baross utca 27, Budapest 1088, Hungary.
Györgyi FekécsDepartment of Obstetrics and Gynecology, Semmelweis University, Baross utca 27, Budapest 1088, Hungary.
Patrik PlankDepartment of Animal Biotechnology, Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Györgyi Albert utca 4, Gödöllő 2100, Hungary.
Zsófia MolnárDepartment of Animal Biotechnology, Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Györgyi Albert utca 4, Gödöllő 2100, Hungary.
György NagyériDepartment of Animal Biotechnology, Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Györgyi Albert utca 4, Gödöllő 2100, Hungary.
Katalin PostaDepartment of Microbiology and Applied Biotechnology, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Györgyi Albert utca 4, Gödöllő 2100, Hungary.
Nándor ÁcsDepartment of Obstetrics and Gynecology, Semmelweis University, Baross utca 27, Budapest 1088, Hungary.
Szabolcs VárbíróDepartment of Obstetrics and Gynecology, University of Szeged, Semmelweis utca 1, Szeged 6725, Hungary.
Levente SáraDepartment of Obstetrics and Gynecology, Semmelweis University, Baross utca 27, Budapest 1088, Hungary.
Zsuzsanna SzőkeDepartment of Animal Biotechnology, Agribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Genetics and Biotechnology, Hungarian University of Agriculture and Life Sciences, Szent-Györgyi Albert utca 4, Gödöllő 2100, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glyphosate (GLY), a widely used herbicide classified as a probable human carcinogen, has an unclear role in hormone-dependent malignancies. This cross-sectional study investigated the presence and elevated concentration of this compound in endometrial tissues and its potential link to uterine cancers, also exploring interactions with other natural environmental contaminants such as mycotoxin Zearalenone (ZEN). Patients with endometrial cancers and age- and Body Mass Index-matched controls with benign endometrial diseases were recruited. Serum and excised endometrial tissue samples were analyzed for GLY, ZEN, and related physiological-hormonal indicators. Results revealed significantly elevated serum GLY levels in patients with high-grade endometrial cancer compared to controls (p < 0.05). Similarly, endometrial tissues from cancer patients, particularly those with high-grade malignancy, exhibited higher GLY levels than controls. Notably, GLY concentrations were significantly greater in endometrial tissue than in serum across all participant groups. No significant correlations were found between hormonal/physiological indicators and GLY levels. A strong positive correlation was observed between endometrial GLY and ZEN levels. This study is among the first to detect the presence and elevated concentration of GLY in human endometrial tissue, raising concerns that GLY exposure may be a significant factor in hormone-dependent diseases, particularly those mediated by estrogen or estrogen-like substances. The findings also highlight the need for further research into the endocrine-disrupting effects and long-term health consequences of GLY and various mycotoxins, as well as their potential synergistic involvement in the development of uterine cancers.

Indexed as

endometrial cancerendometrial tissueglyphosatemycotoxinszearalenone

Identifiers

PMID42088831
PMCPMC13136642

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.