Trial reportJournal of pain research2026
Dixon Up-and-Down Method for Optimizing Oxycodone Dosage in Painless Colonoscopy.
Trial report in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim: Inadequate analgesia during painless colonoscopy can result in undesirable body movements, undermining patient safety and procedural success. Oxycodone, known for its dual κ- and μ-receptor agonism, may provide effective analgesia with a reduced incidence of adverse effects compared to other opioids. However, the optimal intravenous dose of oxycodone for suppressing body movement during colonoscopy has not been established. Methods: This prospective, single-center, dose-finding study enrolled adult patients scheduled for painless colonoscopy. All participants received intravenous oxycodone in combination with propofol, with the oxycodone dose determined according to the Dixon and Massey up-and-down sequential allocation method. The primary outcome was the median effective dose (ED Results: A total of 36 patients were enrolled. The calculated ED Conclusion: Intravenous oxycodone, when dosed by the Dixon up-and-down method, is effective and safe for analgesia during painless colonoscopy. Clinical Trial Registration: ChiCTR:ChiCTR2300077446.
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