ArticleFrontiers in pediatrics2026
Clinical manifestations in children with parechovirus A and respiratory tract infection.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The role of parechovirus A (PeV-A) in respiratory tract infections (RTI) in children remains unclear. Objectives and methods: We used clinical and virological data from two observational studies to study PeV-A in RTIs in children: a study of children admitted to hospital with RTI, and a study of children examined for RTI while attending day care centres. All had clinical examination and one nasopharyngeal aspirate analysed for PeV-A and 18 other viruses and bacteriae by culture and PCR-tests. Results: In the hospital study 4.6% (15/323) PeV-A positive RTIs were single virus detections. In 95.4% (308/323) other viruses were co-detected, including 28 with PeV-A and respiratory syncytial virus (RSV) and 77 with PeV-A and human rhinovirus (HRV). Multivariable logistic regression analysis showed strong association between single PeV-A and upper RTI (URTI) vs. lower RTI (LRTI) (age-adjusted OR 11.3, 95% CI 3.1-41.3). By retrospective evaluation of medical records, PeV-A was a likely cause of mainly pharyngitis and tonsillitis in 10/15 children with single PeV-A. In multivariable logistic regression modelling the presence of PeV-A had no impact on clinical manifestations and short-term outcomes in children with codetected RSV and HRV. In the day-care study PeV-A was detected in 30 children, among who 8/10 with single PeV-A had pharyngitis and tonsillitis. Conclusion: Single PeV-A detection was associated with pharyngitis and tonsillitis among children in day-care and hospital. Most hospitalized children with PeV-A had LRTI and viral codetections, but the presence of PeV-A did not impact disease severity in those with RSV and HRV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.