ArticleProceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition2025
Stability of single-subject estimation of glutamate and GABA dynamics in concurrent fMRI-fMRS at 7 T.
Shahrokh Abbasi-Rad, Robert Frost, Jean Augustinack, Zoe Kourtzi, Uzay Emir, André van der Kouwe
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In one paragraphArticle in Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
6 authors.
Shahrokh Abbasi-RadDepartment of Radiology, Harvard Medical School, Boston, MA, United States.
Robert FrostDepartment of Radiology, Harvard Medical School, Boston, MA, United States.
Jean AugustinackDepartment of Radiology, Harvard Medical School, Boston, MA, United States.
Zoe KourtziDepartment of Psychology, University of Cambridge, Cambridge, United Kingdom.
Uzay EmirDepartment of Radiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
André van der KouweDepartment of Radiology, Harvard Medical School, Boston, MA, United States.
Funding
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8MDevelopment of whole-brain in vivo 2HG imaging for precision medicine in mutant IDH gliomaR01CA211080 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Ovidiu C Andronesi · 2017 to 2026
$5.4MDevelopment of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patientsR01CA255479 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI ANDRONESI, OVIDIU C · 2021 to 2025
$3.0MNeuroimaging and gut microbiome markers of development in HIV-exposed uninfected infantsR01HD093578 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HOLMES, MARTHA, KABA, MAMADOU · 2017 to 2022
$2.9MExtension of a longitudinal cognitive and brain imaging study of early-treated perinatally HIV infected children through adolescenceR01HD099846 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI LAUGHTON, BARBARA, MEINTJES, ERNESTA MARIA · 2019 to 2023
$2.7MNeural correlates of in utero HIV and ART exposure: early childhood follow-up of a prospectively recruited cohortR01HD110152 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI Barbara Laughton, Ernesta Maria Meintjes · 2023 to 2026
$2.4MRobust Precision Mapping of Cortical and Subcortical Brain Metabolic Signatures in ADR01AG079422 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LEE, PHIL, VAN DER KOUWE, ANDRE JAN WILLEM · 2023 to 2025
$2.4MComprehensive prospective correction of head motion in functional MRIR01EB035560 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Stephen Robert Frost · 2024 to 2026
$2.2MA Storage Area Network for Structural and Functional Image AnalysisS10RR023401 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE · 2009 to 2009
$2.0MFetal Neuroprotection by choline supplementation in heavy drinking pregnant womenR01AA030014 · NIAAA · MASSACHUSETTS GENERAL HOSPITAL · PI ROBERT COLIN CARTER, SANDRA W. JACOBSON · 2023 to 2026
$1.9MSILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5MSequence-universal high-frequency prospective MRI motion correction with navigatorsR21EB029641 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI FROST, STEPHEN ROBERT · 2021 to 2023
$665kNCI NIH HHS R01 CA211080NCI NIH HHS R01 CA255479NCRR NIH HHS S10 RR019307NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIAAA NIH HHS R01 AA030014NIA NIH HHS R01 AG079422NIBIB NIH HHS P41 EB015896NIBIB NIH HHS R01 EB035560NIBIB NIH HHS R21 EB029641NICHD NIH HHS R01 HD093578NICHD NIH HHS R01 HD099846NICHD NIH HHS R01 HD110152
6 · The paper itselfAbstract
Motivation: Measuring neurochemical dynamics, particularly the concentrations of GABA and glutamate, at the single-subject level remains challenging due to the low SNR when a small number of transients are used in the averaging window. Goals: To assess the impact of different averaging window sizes on the stability of GABA and glutamate concentration estimates during the time-course of a visual stimulation experiment. Approach: We analyzed the data using various averaging window sizes to evaluate their effect on concentration stability. Results: Detecting single-subject changes in Glutamate and GABA remains challenging, even with a window size of 16 representing the largest practical window size in our experiments. Impact: In single-subject fMRS, choosing averaging window sizes with sufficient SNR is important for reliable measurements of glutamate and GABA dynamics. Further technical development both on the analysis side (temporal fitting) and acquisition side (real-time frequency drift correction) should be explored.
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Data ProcessingSpectroscopy
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PMID42088739
PMCPMC13138719
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