Evidence map›Paper›PMID 42088607›Full record

ArticleNAR cancer2026

Sensitive detection of somatic mutations in GC-rich cancer gene promoters.

Meifang Qi, Preshita Sanjay Dave, Nicole Francis, Matthew DeFelice, Sam Pollock, Holly Corbitt, Irene Rin Mitsiades, Gengchao Wang, Paul Frere, Alan Fox and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Meifang QiKrantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 Boston, MA, United States.
Preshita Sanjay DaveKrantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 Boston, MA, United States.
Nicole FrancisBroad Institute of MIT and Harvard, Cambridge, MA 02142, United States.
Matthew DeFeliceBroad Institute of MIT and Harvard, Cambridge, MA 02142, United States.
Sam PollockBroad Institute of MIT and Harvard, Cambridge, MA 02142, United States.
Holly CorbittTwist Bioscience South San Francisco, California, CA 94080, United States.
Irene Rin MitsiadesKrantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 Boston, MA, United States.
Gengchao WangKrantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 Boston, MA, United States.
Paul FrereTwist Bioscience South San Francisco, California, CA 94080, United States.
Alan FoxTwist Bioscience South San Francisco, California, CA 94080, United States.
Gregory KhitrovTwist Bioscience South San Francisco, California, CA 94080, United States.
Caroline PetersenBroad Institute of MIT and Harvard, Cambridge, MA 02142, United States.
Katie LarkinBroad Institute of MIT and Harvard, Cambridge, MA 02142, United States.
Susanna HamiltonBroad Institute of MIT and Harvard, Cambridge, MA 02142, United States.
Leif W EllisenKrantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 Boston, MA, United States.
Doga C GulhanKrantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 Boston, MA, United States.
Alfredo Hidalgo-MirandaLaboratorio de Genomica del Cancer, Instituto Nacional de Medicina Genomica, Periferico Sur 4809, Arenal Tepepan, Mexico City 14610, Mexico.
Niall LennonBroad Institute of MIT and Harvard, Cambridge, MA 02142, United States.
Carrie CibulskisBroad Institute of MIT and Harvard, Cambridge, MA 02142, United States.
Esther RheinbayKrantz Family Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA 02129 Boston, MA, United States.ORCID 0000-0002-5566-6729

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Somatic mutations in protein-coding genes and noncoding regulatory regions are the major drivers of cancer. Only a relatively small number of somatic noncoding mutations that are likely drivers have been described to date, including those in the promoters of the

Indexed as

Breast NeoplasmsGC Rich SequenceMutationPromoter Regions, GeneticCell Line, TumorCyclin-Dependent Kinase 4DNA Mutational AnalysisFemaleGATA3 Transcription FactorHigh-Throughput Nucleotide SequencingHumansSmad3 ProteinCyclin-Dependent Kinase 4GATA3 Transcription FactorSmad3 ProteinSMAD3 protein, human

Identifiers

PMID42088607
PMCPMC13136893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.