ArticleIBRO neuroscience reports2026
Association between serum cytokine and neuron-specific enolase levels and the core symptoms of autism spectrum disorder.
Article in IBRO neuroscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Investigating alterations in blood cytokine and brain enzyme levels in autism spectrum disorder (ASD) is crucial for understanding its complex pathogenesis. Method: Between January 2021 and December 2024, all children diagnosed with ASD at the First Affiliated Hospital of Anhui Medical University who met the inclusion criteria were consecutively enrolled. Among them, 26 presented with typical features and 15 with atypical features. A control group of 24 age- and sex-matched healthy children was recruited from unrelated families. Serum levels of cytokines (IL-2R, IL-1β, IL-6, IL-8, IL-10, TNF-α) and neuron-specific enolase (NSE) were measured by Enzyme-Linked Immunosorbent Assay, and their associations with the core symptoms of ASD were analyzed. Results: The ASD and control group showed statistically significant differences in serum IL-2R ( Conclusion: In this cross-sectional study, serum cytokines (IL-2R, TNF-α) and NSE were found to be associated with ASD. The combination of NSE with cytokines such as IL-2R and TNF-α may may be associated with distinct clinical features in children with ASD.
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