ArticleInfection and drug resistance2026
Analysis of Genetic Characteristics, Biofilm Formation Ability, and Mortality Risk Factors in Patients Infected with Carbapenem-Resistant
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Genomic characterization of carbapenem-resistantFrontiers in cellular and infection microbiology · 2026Article
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6 authors.
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Abstract
Purpose: This study aims to investigate the prevalence of resistance genes, efflux pump genes, and biofilm-forming genes in carbapenem-resistant Methods: This study included 244 patients with CRAB infections admitted to a tertiary hospital in Zhangjiakou, China, between June 2021 and December 2024. Statistical analysis was performed using SPSS 27.0 software to investigate potential risk factors for mortality associated with CRAB. Conventional PCR amplification was used to qualitatively detect resistance genes, efflux pump genes, and biofilm-related genes in isolated CRAB strains. Biofilm formation capacity was assessed using the crystal violet staining method. The study analyzed the association between the aforementioned genetic and phenotypic characteristics, biofilm formation capacity, and antibiotic resistance. Results: A total of 244 CRAB isolates were collected in this study, primarily from sputum (55.33%), followed by bronchoalveolar lavage fluid (26.23%). The majority of isolates originated from the ICU (48.77%), followed by the Department of Respiratory Medicine (31.15%). PCR results showed that the predominant resistance genes in CRAB isolates from this hospital were Conclusion: In this study, CRAB strains were primarily isolated from the lungs (81.56%) and mainly originated from the ICU and respiratory department. CRAB strains exhibited extremely high resistance rates to most commonly used antimicrobial agents; specifically, resistance rates to 9 antimicrobial agents, including piperacillin/tazobactam, imipenem, and meropenem, were all >90%. Only tigecycline showed a relatively low resistance rate (3.08%), and no resistance to polymyxin was detected. The CRAB strains in our hospital primarily harbor the
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