Evidence map›Paper›PMID 42088475›Full record

ArticleJournal of family & reproductive health2025

Evaluating the Impact of Hyaluronic Acid on Sperm Quality Before and After Cryopreservation in A Moroccan Cohort: A Pilot Study.

Mehdi El Mokaddem, Zeineb Zian, Amr Kchikich, Noureddine Louanjli, Naima Ghailani Nourouti, Amina Barakat, Moudou M Mbaye, Mohcine Bennani Mechita

Abstract read
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In one paragraph

Article in Journal of family & reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mehdi El MokaddemIntelligent Automation and BioMed Genomics Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco.
Zeineb ZianIntelligent Automation and BioMed Genomics Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco.
Amr KchikichLaboratory of Biotechnological Valorization of Microorganisms, Genomics, and Bioinformatics, Faculty of Sciences and Techniques, University Abdelmalek Essaadi, Tetouan, Morocco.
Noureddine LouanjliLaboratory of Medical Analysis, Andrology Department, LABOMAC, Casablanca, Morocco.
Naima Ghailani NouroutiIntelligent Automation and BioMed Genomics Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco.
Amina BarakatIntelligent Automation and BioMed Genomics Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco.
Moudou M MbayeLaboratory of Medical Analysis, Andrology Department, LABOMAC, Casablanca, Morocco.
Mohcine Bennani MechitaIntelligent Automation and BioMed Genomics Laboratory, Faculty of Sciences and Techniques of Tangier, Abdelmalek Essaadi University, Tetouan, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to evaluate the effects of hyaluronic acid (HA) supplementation on motility, vitality, and DNA integrity in Moroccan fresh and cryopreserved sperm samples. Materials and methods: A cohort of 60 male participants was divided into three groups, including normozoospermic, asthenozoospermic, and cryopreserved normozoospermic samples. Advanced microscopy and computer-assisted semen analysis (CASA) were used to analyze the sperm parameters before and after HA supplementation. DNA fragmentation was analyzed using TUNEL assay, while chromatin condensation was evaluated by aniline blue staining. Statistical analysis was performed using ANOVA and Duncan's test. Results: HA supplementation improved sperm motility and vitality ( Conclusion: HA is a promising adjuvant for enhancing the quality of both fresh and cryopreserved sperm for ART without compromising DNA integrity. Studies need to be extended for further exploration of the mechanism of action and optimization of clinical protocols toward its use in routine practice, particularly for diverse populations and in the more difficult cases of infertility.

Indexed as

CryopreservationFertilityHyaluronic AcidMale infertilityMorocco

Identifiers

PMID42088475
PMCPMC13138347

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.