Evidence map›Paper›PMID 42088437›Full record

ArticleInternational journal of biological sciences2026

TGFβR Hyperactivation Drives CD103⁺/ITGB2⁺ TRM Cell Accumulation in High-Fat Diet-Exacerbated CIA.

Sijia Yan, Jielin Sun, Khan Zara Ahmad, Xuan Wang, Lei Tong, Qiangdongzi Mao, Qingwen Wang, Adeleh Divsalar, Edwin Cheung, Chaofu Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sijia YanDepartment of Pathology, Ruijin Hospital and College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Jielin SunInstitute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Khan Zara AhmadDepartment of Laboratory Medicine, Division of Pathology, Karolinska Institutet, Stockholm 17177, Sweden.
Xuan WangDepartment of Pathology, Ruijin Hospital and College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Lei TongDepartment of Anesthesiology and Surgical Intensive Care Unit, School of Medicine and School of Biomedical Engineering, Xinhua Hospital, Shanghai Jiao Tong University, 200240, Shanghai, China.
Qiangdongzi MaoDepartment of Anesthesiology and Surgical Intensive Care Unit, School of Medicine and School of Biomedical Engineering, Xinhua Hospital, Shanghai Jiao Tong University, 200240, Shanghai, China.
Qingwen WangDepartment of Anesthesiology and Surgical Intensive Care Unit, School of Medicine and School of Biomedical Engineering, Xinhua Hospital, Shanghai Jiao Tong University, 200240, Shanghai, China.
Adeleh DivsalarDepartment of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi University, Tehran 15719-14911, Iran.
Edwin CheungCancer Centre, Centre for Precision Medicine Research and Training, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau SAR.
Chaofu WangDepartment of Pathology, Ruijin Hospital and College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xu WangDepartment of Pathology, Ruijin Hospital and College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Xianting DingDepartment of Anesthesiology and Surgical Intensive Care Unit, School of Medicine and School of Biomedical Engineering, Xinhua Hospital, Shanghai Jiao Tong University, 200240, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity exacerbates rheumatoid arthritis (RA). However, the underlying mechanisms remain incompletely defined. Elucidating these mechanisms can help the identification of novel therapeutic targets. Herein, we used high-fat diet (HFD)-induced obese collagen-induced arthritis (CIA) mice to investigate these mechanisms. Immunohistochemistry revealed that obesity exacerbated joint inflammation and cartilage degradation. Next, integrated label-free quantitative proteomics and cytometry by time-of-flight (CyTOF) were used to characterize lymphocyte subsets. Proteomic profiling identified 26 differentially expressed proteins in obese versus lean CIA mice, including the transcription factors EOMES and KLF2, the TGFβ receptor (TGFβR) signaling component TGFBR2, and the tissue-resident memory (TRM) T cell marker CD103. CyTOF analysis revealed a robust 3.0-fold increase (

Indexed as

Antigens, CDArthritis, ExperimentalArthritis, RheumatoidDiet, High-FatIntegrin alpha ChainsAnimalsMaleMiceObesityReceptor, Transforming Growth Factor-beta Type IIT-Lymphocytesalpha E integrinsAntigens, CDIntegrin alpha ChainsReceptor, Transforming Growth Factor-beta Type IIasiaticosidecollagen-induced arthritisobesityrheumatoid arthritisTGFβR hyperactivationtissue-resident memory T cells

Identifiers

PMID42088437
PMCPMC13137863

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.