TRIM47-mediated Ubiquitination of p53 Controls Proliferative Progression and Stress Adaptation in Glioblastoma.

Dakun Pei, Xiaosong Hu, Wen Peng, Hongbo Chang, Yi Du, Man Xu, Ping Liang, Hongjuan Cui

Abstract read

In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

TRIM47 promotes cell viability, cell cycle progression, metabolic reprogramming, and inhibits apoptosis of glioma via the NF-κB signaling pathway.Translational cancer research · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dakun PeiState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.

Xiaosong HuState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.

Wen PengState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.

Hongbo ChangState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.

Yi DuState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.

Man XuJinfeng Laboratory, Chongqing, 400716, China.

Ping LiangDepartment of Neurosurgery, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China.

Hongjuan CuiState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is a highly aggressive malignancy characterized by dysregulated cell proliferation and impaired stress-response control. Here, we identify the E3 ubiquitin ligase TRIM47 as a regulator of p53 proteostasis and proliferative signaling in GBM. Integrated bioinformatic analyses and immunohistochemistry revealed that TRIM47 is upregulated in GBM and associated with unfavorable survival. Functional assays demonstrated that TRIM47 depletion suppressed GBM cell proliferation and clonogenic growth, induced G1-phase arrest, and markedly inhibited intracranial tumor growth

Indexed as

GlioblastomaTumor Suppressor Protein p53AnimalsCell CycleCell Line, TumorCell ProliferationDNA DamageHumansMiceSignal TransductionUbiquitinationUbiquitin-Protein LigasesTumor Suppressor Protein p53Ubiquitin-Protein Ligasescell cyclecell proliferationglioblastomap53TRIM47ubiquitination

Identifiers

PMID42088429

DOI10.7150/ijbs.131392

PMCPMC13137981

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.