Evidence map›Paper›PMID 42088421›Full record

ArticleInternational journal of biological sciences2026

Novel strategies for mitigating hepatic ischemia-reperfusion injury: targeting MICU1 and calcium-glycolytic homeostasis with acteoside.

Yinhao Zhang, Runping Liu, Yun Yang, Huayao Lu, Mengyu Guo, Hong Wang, Ranyi Luo, Xiaoyong Xue, Guifang Fan, Kaihong Xie and 2 more

Abstract read
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yinhao ZhangSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.
Runping LiuSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 100029, China.
Yun YangSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.
Huayao LuSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.
Mengyu GuoSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.
Hong WangSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.
Ranyi LuoSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.
Xiaoyong XueSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.
Guifang FanSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 100029, China.
Kaihong XieSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.
Jia LiuSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.
Xiaojiaoyang LiSchool of Life Sciences, Beijing University of Chinese Medicine, 100029, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic ischemia-reperfusion injury (HIRI) contributes to metabolic disorders within hepatic sinusoid and frequently occurs during liver transplantation, yet its underlying mechanisms and intervention strategies remain obscure. This study aimed to elucidate whether acteoside (ACT) improved HIRI by repairing mitochondrial calcium uptake 1 (MICU1)-mediated Ca

Indexed as

CalciumCalcium-Binding ProteinsGlucosidesLiverMitochondrial Membrane Transport ProteinsPhenolsReperfusion InjuryAnimalsEndoplasmic ReticulumGlycolysisHomeostasisMaleMiceMice, Inbred C57BLCalciumCalcium-Binding ProteinsGlucosidesMICU1 protein, mouseMitochondrial Membrane Transport ProteinsPhenolsacteosidecalcium ionHIRIlactylationlipid nanoparticlesLSEC

Identifiers

PMID42088421
PMCPMC13137855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.