Evidence map›Paper›PMID 42088414›Full record

ArticleInternational journal of biological sciences2026

Tumor Necrosis Factor Receptor 2 Inhibits HIV-1 Infection by Blocking the Binding of gp120 to CD4.

Yang Gao, Zhonghao Chen, Yibo Chen, Yang Yang, Yiru Wang, Ci Zhu, Ping Liao, He Song, Xin Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yang GaoInstitute of Chinese Medical Sciences, State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macau SAR, China.
Zhonghao ChenInstitute of Chinese Medical Sciences, State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macau SAR, China.
Yibo ChenInstitute of Chinese Medical Sciences, State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macau SAR, China.
Yang YangInstitute of Chinese Medical Sciences, State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macau SAR, China.
Yiru WangInstitute of Chinese Medical Sciences, State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macau SAR, China.
Ci ZhuInstitute of Chinese Medical Sciences, State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macau SAR, China.
Ping LiaoInstitute of Chinese Medical Sciences, State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macau SAR, China.
He SongInstitute of Chinese Medical Sciences, State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macau SAR, China.
Xin ChenInstitute of Chinese Medical Sciences, State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macau SAR, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The HIV-1 envelope glycoprotein gp120 binds to the CD4 molecule and then undergoes conformational changes to interact with the co-receptors CCR5 or CXCR4, resulting in cellular entrance. However, certain types of cells, such as macrophages and CD4

Indexed as

CD4 AntigensCD4-Positive T-LymphocytesHIV Envelope Protein gp120HIV InfectionsReceptors, Tumor Necrosis Factor, Type IIHEK293 CellsHumansJurkat CellsReceptors, CCR5CCR5 protein, humanCD4 Antigensgp120 protein, Human immunodeficiency virus 1HIV Envelope Protein gp120Receptors, CCR5Receptors, Tumor Necrosis Factor, Type IITNFRSF1B protein, humangp120HIV-1pseudovirusTNFTNFR1TNFR2

Identifiers

PMID42088414
PMCPMC13137973

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.