The UFSP2-C1orf27 complex positions nascent GPCRs to the ufmylation system for ER export control.

Xin Xu, Yinquan Fang, Lifen Qiu, Wei Huang, Honglin Li, Guangyu Wu

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Xin XuDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Yinquan FangDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Lifen QiuDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Wei HuangDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Honglin LiDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Guangyu WuDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Funding

GPCR anterograde traffickingR35GM136397 · NIGMS · AUGUSTA UNIVERSITY · PI GUANGYU WU · 2020 to 2026

$2.7M

NIGMS NIH HHS R35 GM136397

6 · The paper itself

Abstract

The ufmylation system is implicated in multiple cellular processes and human diseases; our recent study has identified its function in protein trafficking, but detailed mechanisms remain elusive. Here, we reveal cooperative actions of ufmylation protease UFSP2 and endoplasmic reticulum (ER)-anchored protein C1orf27 on ER-to-Golgi transport of some G protein-coupled receptors (GPCRs). UFSP2 interacts with C1orf27 for ER recruitment, and its activation is dispensable for recruitment but essential for ER export of GPCRs. Structural analysis suggests that UFSP2 and C1orf27 are diverged from a

Indexed as

BiochemistryCell biologyMolecular biology

Identifiers

PMID42088365

DOI10.1016/j.isci.2026.115707

PMCPMC13137144

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.