Evidence map›Paper›PMID 42088356›Full record

ArticleiScience2026

Endometrial NCOR1 deficiency contributes to implantation failure in endometriosis-associated infertility.

Loan Thi Kim Nguyen, Dinh Nam Tran, Johan Auwerx, Harini Raghu Kumar, Steven L Young, Bruce A Lessey, Ripla Arora, Jung-Yoon Yoo, Tae Hoon Kim, Jae-Wook Jeong

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Loan Thi Kim NguyenDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, Columbia, MO 65211, USA.
Dinh Nam TranDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, Columbia, MO 65211, USA.
Johan AuwerxLaboratory of Integrative Systems Physiology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Harini Raghu KumarDepartment of Obstetrics, Gynecology and Reproductive Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.
Steven L YoungDepartment of Obstetrics, Gynecology and Women's Health, Duke University, Durham, NC 27708, USA.
Bruce A LesseyDepartment of Obstetrics and Gynecology, Atrium Health Wake Forest Baptist, Winston-Salem, NC 27101, USA.
Ripla AroraDepartment of Obstetrics, Gynecology and Reproductive Biology, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA.
Jung-Yoon YooDepartment of Biomedical Laboratory Science, Yonsei University Mirae Campus, Wonju 26493, Republic of Korea.
Tae Hoon KimDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, Columbia, MO 65211, USA.
Jae-Wook JeongDepartment of Obstetrics, Gynecology and Women's Health, University of Missouri School of Medicine, Columbia, MO 65211, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis-associated infertility is a complex condition in which the presence of endometrial-like tissue disrupts implantation and early pregnancy. Epigenetic regulators are critical for implantation and decidualization, yet their contribution to endometriosis-associated infertility remains incompletely understood. Nuclear receptor corepressor 1 (NCOR1), an epigenetic coregulator of steroid hormone signaling, has an incompletely defined role in endometriosis and early pregnancy. We show that NCOR1 expression is significantly reduced in the eutopic endometrium of infertile women with endometriosis. Using a conditional uterine

Indexed as

EpigeneticsMolecular geneticsMolecular mechanism of gene regulation

Identifiers

PMID42088356
PMCPMC13138241

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.