ArticleiScience2026
Immune infiltration is associated with distinct transcriptional states and metabolic profiles in chordomas.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
Chordomas are ultra-rare malignancies of the axial skeleton with limited treatment options. Some tumors exhibit immunogenic features and respond to checkpoint blockade, but the biological determinants remain unclear. To investigate chordoma immunogenicity, we integrated spatial transcriptomic and metabolomic profiling. GeoMx digital spatial profiling was performed on 15 chordomas, analyzing tumor and stromal compartments and comparing inflamed versus non-inflamed tumors. Consecutive sections underwent MALDI mass spectrometry imaging. Key findings were validated by immunohistochemistry. To link transcriptional states with interferon-γ, chordoma cell lines were treated with interferon-γ. Spatial profiling revealed transcriptomic differences between inflamed and non-inflamed tumors across both compartments, and immune infiltration correlated with a broader gene expression repertoire in cancer cells. MSI identified distinct metabolic signatures, including glycogen accumulation in inflamed tumors. However, interferon-γ treatment did not induce
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