Evidence map›Paper›PMID 42088346›Full record

ArticleiScience2026

FOXP1 is differentially active during development of murine vasopressin and oxytocin magnocellular neurons.

Jari B Berkhout, Sophie Trender, Quirin Krabichler, Yuval Podpecan, Felix Franke, Tim Schubert, Peter Burbach, Valery Grinevich, Roger Adan, Henning Fröhlich and 3 more

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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jari B BerkhoutDepartment of Internal Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Sophie TrenderInstitute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Quirin KrabichlerDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Yuval PodpecanInstitute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Felix FrankeInstitute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Tim SchubertInstitute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Peter BurbachDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Valery GrinevichDepartment of Neuropeptide Research in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
Roger AdanDepartment of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
Henning FröhlichInstitute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Ferdinand AlthammerInstitute of Human Genetics, Heidelberg University Hospital, Heidelberg, Germany.
Onno C MeijerDepartment of Internal Medicine, Division Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.
Ahmed MahfouzDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothalamic arginine vasopressin (AVP) and oxytocin (OXT) magnocellular neurons (MCNs), share a developmental lineage. The transcription factors driving specification are yet unknown. Using gene regulatory network analysis on published single-cell RNA-sequencing data of the developing mouse hypothalamus, we identified RORA, EBF3, FOXP1, FOXP2, and BCL11B as candidate transcription factors for differential MCN specification. We modeled developmental gene expression dynamics using computational cell fate mapping, revealing enrichment of EBF3 and BCL11B in the

Indexed as

Developmental biologyMolecular physiologyNeuroscience

Identifiers

PMID42088346
PMCPMC13138059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.