Evidence map›Paper›PMID 42088342›Full record

ArticleiScience2026

HIF1-α induces mitochondrial fission in trophoblastic cells during early pregnancy and in preeclampsia.

Léa Poinsignon, Audrey Chissey, Juliette Colombel, Bertrand Lefrère, Charlotte Izabelle, Lucie Bernard, Jean-Louis Beaudeux, Thierry Fournier, Ioana Ferecatu, Isabelle Hernandez and 1 more

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Léa PoinsignonUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.
Audrey ChisseyUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.
Juliette ColombelUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.
Bertrand LefrèreUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.
Charlotte IzabelleUniversité Paris Cité, Inserm, CNRS, P-MIM, PICMO, 75006 Paris, France.
Lucie BernardUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.
Jean-Louis BeaudeuxUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.
Thierry FournierUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.
Ioana FerecatuUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.
Isabelle HernandezUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.
Amal Zerrad-SaadiUniversité Paris Cité, INSERM, UMR-S 1139 (FPRM), Faculté de Pharmacie de Paris, 75006 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The placenta undergoes a major oxygen transition between 7 and 9 gestation weeks (GW) and 12-14 GW. Inadequate adaptation to these environmental changes leads to oxidative stress and the release of syncytial knots, a hallmark of preeclampsia (PE). As mitochondria play a central role in redox regulation, we investigated mitochondrial network dynamics and the role of hypoxia-inducible factor 1-alpha (HIF1-α) in trophoblasts during early pregnancy and in PE. HIF1-α is stabilized in placenta before 9 GW, associated with mitochondrial hypertubulation and increased mitofusin (MFN) 1 expression. Experimental stabilization of HIF1-α using cobalt chloride induces mitochondrial fission through downregulation of MFN1 and MFN2, and upregulation of dynamin-related protein 1 (DRP1). In pre-eclamptic placentas, significantly elevated mitochondrial fission 1 protein (FIS1) levels suggest enhanced mitochondrial fission, supporting FIS1 as a potential biomarker of PE-associated placental alterations.

Indexed as

cell biologydevelopmental biology

Identifiers

PMID42088342
PMCPMC13138064

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.