Evidence map›Paper›PMID 42088293›Full record

ArticleFrontiers in aging neuroscience2026

Different stages of Alzheimer's disease with periodontitis: clinical features and potential mechanisms involving gingipains, neuropathological biomarkers and neurological damage.

Jing-Hui Li, Teng-Hong Lian, Peng Guo, Jing Li, Jing Qi, Ming-Yue He, Dong-Mei Luo, Ya-Nan Zhang, Gai-Fen Liu, Yue Huang and 8 more

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Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Jing-Hui LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Teng-Hong LianDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Peng GuoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jing LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Jing QiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ming-Yue HeDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dong-Mei LuoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ya-Nan ZhangDepartment of Blood Transfusion, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Gai-Fen LiuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yue HuangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei-Jia ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zi-Jing ZhengDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hao YueDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hui-Ying GuanDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhan LiuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Fan ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yao MengDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Wei ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alzheimer's disease (AD) and periodontitis are common in older adults aged over 65 years. However, the clinical features and mechanisms at the stages of mild cognitive impairment and dementia due to AD (AD-MCI and AD-D) remain unknown. Methods: In 110 patients with AD-MCI and AD-D, oral hygiene, periodontitis status, clinical symptoms and the levels of gingipain, neuropathological biomarkers and neurological damage indicators in cerebrospinal fluid were evaluated. Results: The frequency of periodontitis was 38.18% in the AD-MCI group and 67.27% in the AD-D group. The AD-MCI with periodontitis group had significantly worse cognition and lower β-amyloid (Aβ) level than those without periodontitis (all Conclusion: Periodontitis is more prevalent and severe in AD patients. K-GP plays a significant role in AD with periodontitis, and is associated with AD pathology and impairs cognition at the MCI stage. K-GP contributes to the exacerbation of AD pathology and neurodegeneration, and is potentially involved in the aggravation of symptoms at the dementia stage.

Indexed as

Alzheimer’s diseaseclinical features and potential mechanismsdementiamild cognitive impairmentperiodontitis

Identifiers

PMID42088293
PMCPMC13136118

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