SynthesisFrontiers in public health2026
Comparative effectiveness of non-pharmacological interventions for depression and anxiety in chronic low back pain: a Bayesian network meta-analysis of randomized controlled trials.
Synthesis in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Chronic low back pain (CLBP) is often accompanied by anxiety and depression, which hinders clinical treatment. Therefore, this study conducts a Bayesian network meta-analysis to compare the effectiveness of different non-drug interventions in relieving pain and related emotional symptoms in CLBP patients. Methods: This review was prospectively registered in PROSPERO (CRD420251066414). As of June 2025, PubMed, Embase, Cochrane Library, Web of Science, CINAHL, Scopus, CNKI, and Wanfang databases have been searched to collect randomized controlled trials concerning non-pharmacological interventions for CLBP. The main outcomes are pain, anxiety, and depression. The scoring directions of all outcome scales were consistent. To account for differences in measurement tools, effect sizes are expressed as standardized mean differences (SMD), estimated using a Bayesian random-effects model based on change scores, and reported with 95% credible intervals (CrIs), adjusted using Hedges' g. Comprehensive sensitivity analysis, subgroup analysis, and regression analysis were carried out to explore the source of heterogeneity and the factors affecting the treatment results. Results: Twenty-four trials were ultimately included ( Conclusion: MBE and SE may help alleviate pain, anxiety, and depression among CLBP individuals, whilst IR may have a modest beneficial impact on depression. Given the high heterogeneity across different outcome measures, these conclusions should be evaluated with caution, and further high-quality research is required to substantiate them. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420251066414, PROSPERO, CRD420251066414.
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