ArticleJournal of anaesthesiology, clinical pharmacology
Double relief: A systematic review and meta-analysis of intravenous ketamine and morphine combination for acute trauma analgesia.
Article in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Acute trauma pain often remains inadequately treated despite opioid therapy. Low-dose ketamine has emerged as a promising adjunct analgesic that may enhance morphine effectiveness while reducing opioid requirements. This systematic review assessed the efficacy and safety of morphine combined with low-dose ketamine versus morphine alone for acute trauma analgesia. Material and Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, comprehensive searches were conducted across six databases (2006-2024) for studies comparing morphine-ketamine combination versus morphine monotherapy in acute trauma patients. Six eligible randomized controlled trials (RCTs) ( Results: Six RCTs involving 708 patients from emergency departments and prehospital settings were analyzed. Morphine-ketamine combination demonstrated superior analgesic efficacy with significantly lower final pain scores (mean difference (MD): -0.26; 95% confidence interval (CI): -0.40 to -0.12; Conclusion: Low-dose ketamine as a morphine adjunct improves acute trauma pain control, shows a trend toward reduced opioid requirements, and maintains an acceptable safety profile, supporting its clinical implementation in emergency settings.
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