Evidence map›Paper›PMID 42088071›Full record

ArticleArthroplasty today2026

Intraoperative Liposomal Bupivacaine Is Associated With Reduced Opioid Use and Enhanced Recovery After Total Knee Arthroplasty: A Multicenter Registry Study.

Mitchell K Ng, Jennifer H Lin, Andrew I Spitzer, Vinod Dasa, Adam Rivadeneyra, David Rogenmoser, Andrew L Concoff, Mary DiGiorgi, Joshua Urban, William M Mihalko and 1 more

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In one paragraph

Article in Arthroplasty today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mitchell K NgMaimonides Medical Center, Brooklyn, NY.
Jennifer H LinPacira BioSciences, Inc., Tampa, FL.
Andrew I SpitzerDepartment of Orthopaedic Surgery, Cedars Sinai Medical Center, Los Angeles, CA.
Vinod DasaDepartment of Orthopaedic Surgery, Louisiana State University Health Services Center, New Orleans, LA.
Adam RivadeneyraOrthopaedic Specialty Institute, Orange, CA.
David RogenmoserMid State Orthopaedic & Sports Medicine Center, Alexandria, LA.
Andrew L ConcoffExagen Inc., Vista, CA.
Mary DiGiorgiPacira BioSciences, Inc., Tampa, FL.
Joshua UrbanOrthoNebraska, Omaha, NE.
William M MihalkoDepartment of Orthopaedic Surgery, University of Tennessee Health Science Center, Campbell Clinic Orthopaedics, Memphis, TN.
Michael A MontDepartment of Orthopaedic Surgery, Sinai Hospital of Baltimore, Baltimore, MD.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: With an annual volume of total knee arthroplasties (TKAs) in the United States projected to exceed 1.5 million by 2050, optimizing perioperative pain control and facilitating early discharge remain clinical priorities. This study evaluated the effectiveness of liposomal bupivacaine (LB) vs conventional bupivacaine/ropivacaine in opioid-naïve patients undergoing primary TKA, comparing/contrasting: (1) pain score improvements, (2) opioid usages, (3) functional recoveries, and (4) hospital lengths of stay. Methods: Data from the Innovations in Genicular Outcomes Research (iGOR) registry were used to identify patients undergoing unilateral primary TKA between September 2021 and December 2024. Two hundred twenty-five patients were analyzed, 42 receiving LB and 183 receiving conventional local anesthetics. Patients were stratified based on intraoperative analgesia; pain was assessed using the Brief Pain Inventory-Short Form; opioid use was self-reported; function was measured with the Knee Injury and Osteoarthritis Outcome Score for Joint Replacement. Comparative analyses were performed using generalized linear mixed-effects regressions, with significance Results: The LB group showed lower average Brief Pain Inventory-Short Form scores in the early postoperative period (2.6 vs 2.9; Conclusions: Use of LB is associated with improved pain control, reduced opioid use, and shorter lengths of stay following TKA. This study highlights LB's utility in facilitating early mobilization and advancing perioperative care.

Indexed as

Liposomal bupivacaineOpioid reductionPatient-reported outcomesPostoperative pain managementReal-world registryTotal knee arthroplasty

Identifiers

PMID42088071
PMCPMC13136766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.