ArticleFrontiers in plant science2026
Erythromycin induces lipid redistribution and toxicological effect of the marine diatom
Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Erythromycin poses significant ecological risks to marine ecosystem due to its persistence and lipophilic properties. However, the response mechanism of marine microalgae to erythromycin remains inadequately understood. Methods: Results: High-dose erythromycin exposure concentration-dependently inhibited algal growth, disrupted photosynthetic pigments, and induced oxidative stress. Notably, erythromycin triggered a pronounced lipid redistribution, characterized by altered glycerolipid and glycerophospholipid profiles, increased lipid accumulation, and enhanced unsaturated fatty acid profile. Transcriptomic analyses confirmed that ERY-induced lipidome remodeling affected critical pathways to provide precursors and reducing power degradation for fatty acid synthesis, and the pathway of fatty acid degradation. Conclusion: These findings elucidate the intrinsic mechanistic link between antibiotic-induced lipid dysregulation and the physiological resilience of diatoms, providing novel insights into the molecular toxicology of antibiotics in primary producers.
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