Evidence map›Paper›PMID 42088032›Full record

SynthesisDepression and anxiety2026

Individual Participant Data Meta-Analysis Identifies Risk Factors for Acute and Persistent Posttraumatic Stress Disorder and Depression Symptoms Following Trauma.

Andrew Ratanatharathorn, Richard A Bryant, Ronald C Kessler, Katherine M Keyes, Yutaka Matsuoka, Miranda Olff, Renato Polimanti, Andrew G Rundle, Karestan C Koenen, Arieh Y Shalev

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Depression and anxiety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew RatanatharathornDepartment of Epidemiology, TH Chan School of Public Health Harvard University, Boston, Massachusetts, USA, harvard.edu.ORCID https://orcid.org/0000-0001-9855-0438
Richard A BryantSchool of Psychology, University of New South Wales, Sydney, New South Wales, Australia, unsw.edu.au.ORCID https://orcid.org/0000-0002-9607-819X
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA, harvard.edu.ORCID https://orcid.org/0000-0003-4831-2305
Katherine M KeyesDepartment of Epidemiology, Mailman School of Public Health Columbia University, New York, New York, USA, columbia.edu.ORCID https://orcid.org/0000-0002-5624-021X
Yutaka MatsuokaNational Cancer Center Japan Institute for Cancer Control, Tokyo, Japan.ORCID https://orcid.org/0000-0002-8690-8129
Miranda OlffDepartment of Psychiatry, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public Health, Amsterdam Neuroscience, Amsterdam, Netherlands, uva.nl.
Renato PolimantiDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA, yale.edu.ORCID https://orcid.org/0000-0003-0745-6046
Andrew G RundleDepartment of Epidemiology, Mailman School of Public Health Columbia University, New York, New York, USA, columbia.edu.
Karestan C KoenenDepartment of Epidemiology, TH Chan School of Public Health Harvard University, Boston, Massachusetts, USA, harvard.edu.
Arieh Y ShalevDepartment of Psychiatry, Hebrew University of Jerusalem, Jerusalem, Israel, huji.ac.il.ORCID https://orcid.org/0000-0001-9425-050X

Funding

Training Program in Psychiatric Genetics and Translational ResearchT32MH017119 · NIMH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI KARESTAN C KOENEN, Jukka-Pekka Onnela · 1985 to 2026
$8.9M
Identifying Risk Factors for PTSD by Pooled Analysis of Current Prospective StudiR01MH101227 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2014 to 2017
$2.7M
NIMH NIH HHS R01 MH101227NIMH NIH HHS T32 MH017119
6 · The paper itself

Abstract

Background: Posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) are common sequelae to trauma. Identifying individuals at risk for persistent symptomology allows for targeted interventions. Methods: We conducted an individual participant data meta-analysis (IPD-MA) by pooling data from five prospective emergency room and critical care unit studies ( Results: Female sex (odds ratio [OR] range: 1.48-2.14) was associated with increased risk for acute and persistent MDD and PTSD while individuals who experienced an accident versus an assault or other traumatic event as the index trauma were at reduced risk (OR range: 0.39-0.66). Acute MDD symptom severity was associated with persistent PTSD (OR: 1.17; 95% CI: 1.08, 1.27) and remained significant after inclusion of acute PTSD symptom severity (OR: 1.14; 95% CI: 1.01, 1.29). In an analysis of PTSD symptom clusters, reexperiencing symptoms (OR: 1.18; 95% CI: 1.02, 1.36) and MDD symptom severity were associated with persistent PTSD. In models of persistent MDD, acute PTSD symptom severity was associated with persistence (OR: 1.15; 95% CI: 1.03, 1.28), but neither overall symptom severity nor cluster symptom severities were associated with persistence after inclusion of acute MDD symptom severity (OR: 1.13; 95% CI: 1.00, 1.26). Conclusion: Early symptoms of MDD and reexperiencing were associated with the persistence of psychopathology indicating that depressive rumination may play a role in the maintenance of MDD and PTSD.

Indexed as

Major Depressive DisorderStress Disorders, Post-TraumaticAcute DiseaseAdultFemaleHumansMaleRisk FactorsSex Factors

Identifiers

PMID42088032
PMCPMC13138216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.